Reseaarch on the function and development of new therapy for Ion channels in the lower urinary tract

下尿路离子通道的功能研究及新疗法的开发

• 批准号: 21791497
• 负责人: KUDOU Shouji
• 金额: $ 2.75万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791497/
• 关键词: 排尿学; ボツリヌス毒素; 膀胱上皮細胞; 膀胱上皮下の神経細胞; 膀胱上皮下のおよび間質細胞; 機械センサー分子; ENaC; TRP

Boturinum toxin (Botox) has been widely used for refractory overactive bladder(OAB), and its mechanism of action in OAB has been examined. In this study, we have been trying to explore the novel, afferent inhibiton of Botox.In the urine storage phase, mechanical stretch stimulates bladder afferents. These urinary bladder afferent sensory nerves consist of small diameter Aδ-and C-fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. The exact mechanisms that underline mechano-sensory transduction in bladder afferent terminals remain ambiguous.

肉毒杆菌毒素（Boturinum toxin，Botox）已被广泛用于难治性膀胱过度活动症（overactive bladder，OAB），并且其在OAB中的作用机制已被研究。在本研究中，我们一直试图探索肉毒杆菌素的新的传入神经。在储尿阶段，机械牵拉刺激膀胱传入。这些膀胱传入感觉神经由小直径的Aδ-和C-纤维组成，在腹下神经和盆神经中行进。神经解剖学研究揭示了膀胱壁内复杂的神经网络。强调膀胱传入末梢中的机械感觉转导的确切机制仍然不明确。

项目成果

Predictive factors for the effect of the a1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction

α1-D/A 肾上腺素受体拮抗剂萘哌地尔对神经源性下尿路功能障碍患者主客观标准影响的预测因素

• 发表时间: 2011
• 期刊: BJU Int
• 影响因子: 4.5
• 作者: 高橋公太、齊藤和英、中川由紀、田崎正之、原昇;他;Isahaya Etsuko;Hara Noboru;Takizawa Itsuhiro;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;Masayuki Takeda
• 通讯作者: Masayuki Takeda

Masayuki Takeda Operative difficult points in the laparoscopic adrenalecomy for giant pheochromocytoma: comparison between right and left sides

武田正幸 腹腔镜巨大嗜铬细胞瘤肾上腺切除术的手术难点：左右两侧对比

• 发表时间: 2010
• 作者: Hideyasu Inuzuka;Hidenori Zakoji;Tatsuya Miyamoto;Satoru Kira;Syouji Kudou ;Manabu Kamiyama;Norifumi SAWADA;Takayuki Tsuchida;Mizuya Fukasawa;Isao Araki
• 通讯作者: Isao Araki

Ejaculation disorder is associated with increased efficiency of Silodosin for benign prostatic hyperplasia

射精障碍与西洛多辛治疗良性前列腺增生的功效增加有关

• 发表时间: 2011
• 期刊: Urology
• 影响因子: 2.1
• 作者: 高橋公太、齊藤和英、中川由紀、田崎正之、原昇;他;Isahaya Etsuko;Hara Noboru;Takizawa Itsuhiro;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;原昇;Masayuki Takeda;Yukio Homma
• 通讯作者: Yukio Homma

THE EXPRESSION OF TRANSIENT RECEPTOR POTENTIAL (TRP) V4, A1, AND V1 IN THE HUMAN BLADDER MUCOSA OF NORMAL AND BLADDER OUTLET OBSTRUCTION.-A NOvel MECHNISM IN THE OBSTRUCTION-INDUCED BLADDER OVERACTIVITY

正常和膀胱出口梗阻的人膀胱粘膜瞬时受体电位（TRP）V4、A1和V1的表达。-梗阻引起的膀胱过度活动的一种新机制

• 发表时间: 2009
• 作者: Shoji Kudo;Tatsuya Miyamoto;Jiang Yuan Ju;Tsutomu Mochizuki;Hideki Kobayashi;Mitsuharu Yoshiyama;Hidenori Zakohji;Norifumi Sawada;Isao Araki;Kazuya Kawahara;Masayuki Takeda
• 通讯作者: Masayuki Takeda

THE EXPRESSION OF TRANSIENT RECEPTOR POTENTIAL (TRP) V4, A1, AND V1 IN THE HUMAN BLADDER MUCOSA OF NORMAL AND BLADDER OUTLET OBSTRUCTION. -A NOVEL MECHANISM IN THE OBSTRUCTION-INDUCED BLADD ER OVERACTIVITY-

正常和膀胱出口梗阻的人膀胱粘膜中瞬时受体电位 (TRP) V4、A1 和 V1 的表达。

• 发表时间: 2009
• 作者: Shoji Kudo;Tatsuya Miyamoto;Jiang Yuan Ju;Tsutomu Mochizuki;Hideki Kobayashi;Mitsuharu Yoshiyama;Hidenori Zakohji;Norifumi Sawada;Isao Araki;Kazuya Kawahara;Masayuki Takeda;Kudo Shoji
• 通讯作者: Kudo Shoji