Development of cell chip for examination of radiobiological damage

开发用于放射生物学损伤检查的细胞芯片

• 批准号: 21651021
• 负责人: IIDA Toshiyuki
• 金额: $ 1.59万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21651021/
• 关键词: 応答; 細胞損傷; DNA損傷; 放射線応答細胞チップ; 細胞放射線影響; アルファ粒子; 培養細胞; 熱中性子捕獲反応; AmBe中性子線源; 中性子

A cell chip was developed for the examination of biological damage of cells irradiated by high-energyα-rays. A CR-39 track detector was employed as a chip substrate to identify high-energy charged particles traversing target cells. HeLa cancer cells on the chip were irradiated with alpha particles and stained with a fluorescent probe molecule for DNA damage detection. The CR-39 substrate was etched by means of an alkali solution during cell incubation. The HeLa cells andαtracks were successfully observed by microscopy at once

研制了一种细胞芯片，用于检测高能α-射线照射下细胞的生物损伤。采用CR-39轨迹探测器作为芯片衬底，用于识别穿过靶细胞的高能带电粒子。芯片上的HeLa癌细胞用α粒子照射，并用荧光探针分子染色，用于DNA损伤检测。CR-39底物在细胞孵育期间用碱溶液蚀刻。显微镜下成功地观察到HeLa细胞和α轨道

项目成果

Development of a bead-type radiophotoluminescence glass dosimeter applicable to various purposes

开发适用于多种用途的珠型放射光致发光玻璃剂量计

• 发表时间: 2011
• 作者: Y.TOYOTA;F.SATO;I.MURATA;Y.KATO;T.IIDA
• 通讯作者: T.IIDA

X線マイクロビーム照射用神経細胞チップの開発

X射线微束照射神经细胞芯片的研制

• 发表时间: 2009
• 作者: 田中聡戸;稲川千津;青位裕輔;牧大介;佐藤文信;加藤裕史;飯田敏行
• 通讯作者: 飯田敏行

Development of a Remotecontrolled System with the Internet for an Ion Accelerator Aimed at Research and Education on Material Analysis

用于材料分析研究和教学的离子加速器互联网远程控制系统的开发

• 发表时间: 2009
• 期刊: Journal of Eco technology Research 15(1)
• 作者: Kada Wataru;Ishikawa Ippei;Sato Fuminobu;Kato Yushi;Toshiyuki Iida
• 通讯作者: Toshiyuki Iida

Microscopic dose measurement with thin radiophotoluminescence glass plate

使用薄放射光致发光玻璃板进行显微剂量测量

• DOI: 10.1016/j.radmeas.2011.05.051
• 发表时间: 2011
• 期刊: Radiation Measurements
• 影响因子: 2
• 作者: Maki;D.;Nagai;T.;Sato;F.;Kato;Y.;Yamamoto;T.;Iida;T.
• 通讯作者: T.

Development of Cell Chip Based on Track Detector for Examination of Biological Damages by Alpha Particles

开发基于跟踪探测器的细胞芯片，用于检查阿尔法粒子的生物损伤

• DOI: 10.1080/18811248.2010.9720987
• 发表时间: 2010
• 期刊: Journal of Nuclear Science and Technology
• 影响因子: 1.2
• 作者: T. Kuchimaru;F. Sato;S. Tanaka;I. Murata;Y. Kato and T. Iida
• 通讯作者: Y. Kato and T. Iida