Investigation of neuropathology of synucleinopathies using novel model mice.

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To establish useful model animal of Parkinson's Disease(PD) and dementia with Lewy bodies(DLB), transgenic(Tg) mice overexpressing dementia with Lewy bodies(DLB)-linkedβsyn(P123H) were made and analyzedβsyn(P123H) Tg mice mainly showed non-motor symptoms, whereas mice overexpressingβsyn(P123H)/αsyn were characterized by extensive phenotypes, including neuronal cell death. These mice model could be a powerful tool with which to investigate the pathogenic mechanism of PD and DLB.