The physiological activities of lignophenol on the risk-factors of arteriosclerosis

木质素酚的生理活性对动脉硬化危险因素的影响

• 批准号: 21700740
• 负责人: NORIKURA Toshio
• 金额: $ 2.75万
• 依托单位: Aomori University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700740/
• 关键词: 食素材; アディポサイトカイン; 脂肪細胞; リグニン; 脂質異常症; 動脈硬化; メタボリックシンドローム; バイオマス

Adipose tissue is not simply a store of excess energy, but also secretes a variety of hormones called adipocytokines, which are adipose-specific secretory factors. Dysregulated secretion of adipocytokines participates in the pathogenesis of lifestyle-related diseases such as diabetes, hyperlipaemia, hypertension. Accumulation of excess visceral fat caused dysregulated production of adipocytokines. Therefore, regulation of adipocytokines and fat metabolism are important to prevent lifestyle-related diseases.Lignin is one of the components in the plant cell wall, after cellulose, making up 20-30% of the global plant biomass. Lignophenols are derivatives of lignin, which possess high phenolic function and antioxidant properties. However, their medicinal property is not well characterized.In this study, our major findings were as follows :(i) lignophenols decreased oleate-induced hyperlipidemia model in human hepatocellular cells,(ii) lignophenols decreased the mRNA expression of adipocytokine which induced lifestyle-related diseases in mouse adipose cells.The current research outcome would be useful for investigating a potential strategy for the prevention of lifestyle-related diseases through the regulation of lipid and adipocytokine metabolisms.

脂肪组织不仅仅是多余能量的储存，而且还分泌多种称为脂肪细胞因子的激素，这是脂肪特异性的分泌因子。脂肪细胞因子分泌失调参与生活方式相关疾病如糖尿病、高脂血症、高血压的发病机制。过量内脏脂肪的积累导致脂肪细胞因子的产生失调。因此，调节脂肪细胞因子和脂肪代谢对于预防生活方式相关疾病非常重要。木质素是植物细胞壁的成分之一，仅次于纤维素，占全球植物生物量的20-30%。木质素酚是木质素的衍生物，具有较高的酚功能和抗氧化性能。然而，它们的药用特性尚未得到很好的表征。在这项研究中，我们的主要发现如下：（i）木质酚降低了人肝细胞细胞中油酸诱导的高脂血症模型，（ii）木质酚降低了脂肪细胞因子的mRNA表达，脂肪细胞因子在小鼠脂肪细胞中诱导了生活方式相关疾病。目前的研究结果将有助于研究潜在的预防策略 通过调节脂质和脂肪细胞因子代谢来预防与生活方式相关的疾病。

项目成果

Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells., 査読有り, 107, 813-817, (2010)

木质素酚可减少 HepG2 细胞中油酸诱导的载脂蛋白 B 分泌。, 同行评审, 107, 813-817, (2010)

• 发表时间: 2010
• 期刊: Basic Clin.Pharmacol.Toxicol.
• 作者: T. Norikura;Y. Mukai;S. Fujita;K. Mikame;M. Funaoka;S. Sato;T.Norikura
• 通讯作者: T.Norikura

Effect of lignin-derived lignophenols on vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats

木质素衍生的木质酚对链脲佐菌素诱导的糖尿病大鼠血管氧化应激和炎症的影响

• DOI: 10.1007/s11010-010-0645-9
• 发表时间: 2011
• 期刊: Molecular and Cellular Biochemistry
• 影响因子: 4.3
• 作者: Mukai Y;Norikura T;Fujita S;Mikame K;Funaoka M;Sato S
• 通讯作者: Sato S

Lignophenols Decrease Oleate-Induced Apolipoprotein-B Secretion in HepG2 Cells

• DOI: 10.1111/j.1742-7843.2010.00575.x
• 发表时间: 2010-10-01
• 期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
• 影响因子: 3.1
• 作者: Norikura, Toshio;Mukai, Yuuka;Sato, Shin
• 通讯作者: Sato, Shin

Lignin-derived lignophenols attenuate oxidative and inflammatory damage to the kidney in streptozotocin-induced diabeticrats

木质素衍生的木质酚减轻链脲佐菌素诱导的糖尿病大鼠肾脏的氧化和炎症损伤

• 发表时间: 2009
• 期刊: Free Radic.Res. 43
• 作者: S.Sato;Y.Mukai;J.Yamate;T.Norikura;Y.Morinaga;K.Mikame;M.Funaoka;S.Fujita
• 通讯作者: S.Fujita

リグノフェノールによる脂質代謝異常の改善作用

木质素酚对脂质代谢异常的改善作用

• 发表时间: 2010
• 作者: 乗鞍敏夫;向井友花;藤田修三;佐藤伸
• 通讯作者: 佐藤伸