Cancer Preventive Effects of Resveratrol Oligomer-Rich Food Factors with an Antiangiogenic Activity

在体外血管生成模型中，甜菜夜蛾(Gnetum gnemon L.)种子提取物及其主要成分白藜芦醇二聚体Gnetin C可抑制多种血管生成功能，如内皮细胞增殖、迁移和管状形成。在体内，百里香提取物还能抑制肿瘤血管生成、生长和转移。此外，使用基于基因表达特征的方法，发现百里香提取物和Gnetin C的作用模式与拓扑异构酶和细胞周期蛋白依赖的激酶抑制剂相似

In in vitro angiogenesis models, the melinjo (Gnetum gnemon L.) seed extract and its major component gnetin C, a resveratrol dimer, inhibited multiple angiogenic functions, such as endothelial cell proliferation, migration, and tube formation. The melinjo extract also suppressed tumor angiogenesis, growth, and metastasis in vivo. Furthermore, using a gene expression signature-based approach, the modes of action of the melinjo extract and gnetin C were found to be similar to those of topoisomerase and cyclin-dependent kinase inhibitors