Creation of judging method for livestock egg quality based on the molecular mechanism of follicular selection

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Less than 1% of several hundreds of thousand primordial follicles in livestock ovary leads to ovulation, and the rest to selectively disappear by atresia. Many studies in endocrine have been performed but follicle selection mechanism is unknown. We have shown that intracellular signaling pathway of cell death ligand-receptor system that regulates follicle granulosa cell apoptosis is the key to control the follicle selection. In the present project, the factors in this signaling pathway were precisely examined. We indicated that the signal inhibitors are involved in dominant factor to control the follicle selection, and that they are useful as an indicator of oocyte quality determination.