Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C

（目的）针对慢性丙型肝炎的个体化治疗，开展IL28B的基础及临床研究。（方法与结果）临床研究：(1)发现新的候选snp(2)基于IL28B和ITPA snp成功定制治疗。基础研究：(1)IL28B基因表达受snp控制，启动子区表观遗传改变。(2)IL28B的功能分析表明，诱导IFN-λs后的免疫应答可能对hcv感染患者不同的病毒动力学和治疗效果有影响。

(Aim) Toward the tailor-made therapy for chronic hepatitis C, basic and clinical researches of IL28B were conducted. (Methods and Results) Clinical research:(1) Detection of new candidate SNPs(2) Successful tailor-made therapy based on IL28B and ITPA SNPs. Basic research:(1) IL28B gene expression was controlled by SNPs and the epigenetic changes within promoter region(2) Functional analyses of IL28B showed that the induction of IFN-λs followed by immune response might contribute to different viral kinetics and treatment outcome in HCV-infected patients.