Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C

(目的)为量身定制治疗慢性丙型肝炎，开展IL28B的基础和临床研究。(方法和结果)临床研究：(1)新候选SNPs的检测(2)基于IL28B和ITPA SNPs的成功个体化治疗。基础研究：(1)IL-28B基因的表达受SNPs控制，启动子区域的表观遗传学变化；(2)IL-28B的功能分析表明，干扰素-λS的诱导和免疫应答可能是丙型肝炎病毒感染患者不同的病毒动力学和治疗结果的原因之一。

(Aim) Toward the tailor-made therapy for chronic hepatitis C, basic and clinical researches of IL28B were conducted. (Methods and Results) Clinical research:(1) Detection of new candidate SNPs(2) Successful tailor-made therapy based on IL28B and ITPA SNPs. Basic research:(1) IL28B gene expression was controlled by SNPs and the epigenetic changes within promoter region(2) Functional analyses of IL28B showed that the induction of IFN-λs followed by immune response might contribute to different viral kinetics and treatment outcome in HCV-infected patients.