课题基金 / 基金详情

Elucidation of Molecular Mechanism of Cell Death induced by Radiation, Hyperthermia and Ultrasound for Cancer Therapy

Elucidation of Molecular Mechanism of Cell Death induced by Radiation, Hyperthermia and Ultrasound for Cancer Therapy
阐明放射线、热疗和超声治疗癌症时诱导细胞死亡的分子机制
批准号：
22390229
负责人：
KONDO Takashi
金额：
$8.49万
依托单位：
University of Toyama
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390229/
关键词：
放射線腫瘍学超音波治療学温熱治療学ハイパーサーミアアポトーシス放射線超音波TAK1Chk1遺伝子発現がん細胞死治療

项目摘要

项目成果

KONDO Takashi的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Molecular mechanism of cell death induced by ionizing radiation, heat or ultrasound was examined. Stable knockdown of TAK1 caused increase in subG1 fraction and apoptosis induced by X-rays in HeLa cells. Inhibition of DNA-PK increased heat-induced apoptosis in HeLa cells and the knockdown of an identified gene, NR1D1, also enhanced apoptosis. For the cell death induced by ultrasound, cell death signal is modulated by the balance between p53 and Akt via ATM and DNA-PK and the pathway of DNA-PK/Akt is predominant in sonicated cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Ionizing Radiation Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis through Up-Regulations of Death Receptor 4 (DR4) and Death Receptor 5 (DR5) in Human Osteosarcoma Cells
DOI： 10.1002/jor.21056
发表时间： 2010-06-01
期刊： JOURNAL OF ORTHOPAEDIC RESEARCH
影响因子： 2.8
作者： [Hori, Takeshi, Kondo, Takashi, Kimura, Tomoatsu]
通讯作者： Kimura, Tomoatsu
Mitochondria-Targeted Superoxide Dismutase (SOD2) Regulates Radiation Resistance and Radiation Stress Response in HeLa Cells
DOI： 10.1269/jrr.11034
发表时间： 2012-01-01
期刊： JOURNAL OF RADIATION RESEARCH
影响因子： 2
作者： [Hosoki, Ayaka, Yonekura, Shin-Ichiro, Zhang-Akiyama, Qiu-Mei]
通讯作者： Zhang-Akiyama, Qiu-Mei
TGF-beta-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray-irradiated HeLa cells dependent on p21 induction but independent of NF-kB, p38 MAPK and ERK phosphorylations
TGF-β 激活激酶 1 促进 X 射线照射的 HeLa 细胞的细胞周期停滞和细胞存活，依赖于 p21 诱导，但不依赖于 NF-kB、p38 MAPK 和 ERK 磷酸化
DOI： 10.1667/rr2792.1
发表时间： 2012
期刊： Radiat Res
影响因子： 3.4
作者： [Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Li P, Zhao Q-L, Zhao, Nomura T, Saiki I, and Kondo T]
通讯作者： and Kondo T
Hyperthermia enhances the effect of β-lapachone to cause γH2AX formation and cell death in human osteosarcoma cells
热疗增强β-拉帕酮引起人骨肉瘤细胞γH2AX形成和细胞死亡的作用
DOI： --
发表时间： 2011
期刊： Int J Hyperthermia
影响因子： --
作者： [Hori T., et al.]
通讯作者： et al.
共 11 条
    Enhancement of radiation cancer therapy by gold nanorods
    • 批准号：
      18K07668
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.83万
    • 财政年份：
      2018
    • 负责人：
      KONDO Takashi
    • 依托单位：
      University of Toyama
    Effects of a TAK1 inhibitor on radiation-and heat-induced cell killing
    • 批准号：
      26670551
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.16万
    • 财政年份：
      2014
    • 负责人：
      KONDO Takashi
    • 依托单位：
      University of Toyama
    Effect of prostaglandin on the voluntary movement in rats with experimental reflux esophagitis
    • 批准号：
      25860569
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.25万
    • 财政年份：
      2013
    • 负责人：
      KONDO Takashi
    • 依托单位：
      Hyogo Medical University
    Mechanism of Genome Damage Response Induced by Ultrasoun
    • 批准号：
      23650304
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.33万
    • 财政年份：
      2011
    • 负责人：
      KONDO Takashi
    • 依托单位：
      University of Toyama