A retrospective cohort study of the mutual association between periodontal etiology and metabolic syndrome

牙周病因与代谢综合征相互关系的回顾性队列研究

• 批准号: 22390401
• 负责人: YAMASHITA Yoshihisa
• 金额: $ 12.4万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390401/
• 关键词: メタボリックシンドローム; 歯周疾患; 抗体価; 歯周病細菌; 後ろ向きコホート研究

We investigated the effect of serum Porphyromonas gingivalis (Pg) antibody level and general health on periodontal disease in Japanese people. This study included 447 subjects who had the medical and dental check-up in both 2003 and 2011. Excluding the subjects with had missing date, 430 subjects (mean age 58.6 +- 11.1 years, 308 males and 122 females) were analyzed in this study. Periodontal condition was assessed by Community Periodontal Index (CPI) in 2003 and 2011. Serum Pg antibody level in 2003 was measured. Additionally, general health such as overweight, fasting glucose, high-sensitivity C-reactive protein (hs-CRP) was assessed.The percentage of the subjects with CPI code <= 3 (periodontal disease) was 47.8% (males 49.7%, females 43.4%). We defined periodontal condition indicating CPI <= 2 in 2003 and CPI <= 3in 2011 or CPI <= 3 in both 2003 and 2011 as periodontal deterioration. Males and females with periodontal deterioration were 53.2% and 34.4%, respectively. Males and females with highest quintile of serum Pg antibody level were 18.2 and 25.4%. In logistic regression analysis, males having highest quintile of serum Pg antibody level and females with higher level of hs-CRP were more likely to have periodontal deterioration. These results suggest that serum Pg antibody level in males and general inflammation in females predict the incidence of periodontal disease.

我们调查了日本人血清牙龈卟啉单胞菌 (Pg) 抗体水平和总体健康状况对牙周病的影响。这项研究包括 447 名在 2003 年和 2011 年进行过体检和牙科检查的受试者。排除缺席的受试者，本研究分析了 430 名受试者（平均年龄 58.6 ± 11.1 岁，308 名男性和 122 名女性）。 2003年和2011年通过社区牙周指数（CPI）评估牙周状况。测量2003年血清Pg抗体水平。此外，还评估了超重、空腹血糖、高敏C反应蛋白（hs-CRP）等一般健康状况。CPI代码<= 3（牙周病）的受试者比例为47.8%（男性49.7%，女性43.4%）。我们将2003年CPI <= 2和2011年CPI <= 3或2003年和2011年CPI <= 3的牙周状况定义为牙周恶化。男性和女性牙周恶化的比例分别为53.2%和34.4%。血清Pg抗体水平最高五分位的男性和女性分别为18.2%和25.4%。在逻辑回归分析中，血清Pg抗体水平最高五分位数的男性和hs-CRP水平较高的女性更有可能出现牙周恶化。这些结果表明，男性血清 Pg 抗体水平和女性一般炎症水平可预测牙周病的发病率。

项目成果

Population based screening of periodontal disease and its effect on the health behavior of a community

基于人群的牙周病筛查及其对社区健康行为的影响

• 发表时间: 2012
• 作者: Yamashita Yoshihisa;Furuta Michiko;Shimazaki Yoshihiro;Morita Manabu;Adachi Munehisa;Kinoshita Toshinori
• 通讯作者: Kinoshita Toshinori

Relationship between amount of stimulated saliva and oral health status : the Hisayama Study

刺激唾液量与口腔健康状况之间的关系：久山研究

• 发表时间: 2012
• 作者: Oshikohji T;et al;T.Takeshita;竹下徹;Yamashita Y;Shimazaki Y;Fu B
• 通讯作者: Fu B

Gender difference in the association of periodontal status and metabolic syndrome

牙周状况与代谢综合征关联的性别差异

• 发表时间: 2012
• 作者: M Furuta;Y Shimazaki;T Takeshita;Y Shibata;S Akifusa;N Eshima;Y Kiyohara;T Ninomiya;Y Hirakawa;M Mukai;Masaharu N;Y Yamashita;遠藤由美子;前田樹海;Yamashita Yoshihisa
• 通讯作者: Yamashita Yoshihisa

Comparison of oral health environment between Korean and Japanese adult population

韩国与日本成年人口口腔健康环境比较

• 发表时间: 2012
• 作者: Yamashita Yoshihisa;Takeshita Toru;Oralflora;Yamashita Yoshihisa
• 通讯作者: Yamashita Yoshihisa

地域成人集団における刺激唾液分泌量と口腔健康状態との関連性:久山町研究

当地成年人口唾液分泌刺激与口腔健康状况之间的关系：久山镇研究

• 发表时间: 2011
• 作者: 傅博涵;嶋崎義浩;秋房住郎;竹下徹;柴田幸江;清原裕;山下喜久
• 通讯作者: 山下喜久