A retrospective cohort study of the mutual association between periodontal etiology and metabolic syndrome

我们调查了日本人血清牙龈卟啉单胞菌（Pg）抗体水平和一般健康状况对牙周病的影响。这项研究包括447名受试者，他们在2003年和2011年都进行了医疗和牙科检查。排除日期缺失的受试者，本研究分析了430例受试者（平均年龄58.6 ± 11.1岁，308例男性和122例女性）。在2003年和2011年，通过社区牙周指数（CPI）评估牙周状况。检测2003年血清Pg抗体水平。此外，还对超重、空腹血糖、高敏C反应蛋白（hs-CRP）等一般健康状况进行了评估，CPI代码<= 3（牙周病）的受试者比例为47.8%（男性49.7%，女性43.4%）。我们将2003年CPI <= 2和2011年CPI <= 3或2003年和2011年CPI均<= 3的牙周状况定义为牙周恶化。牙周恶化的男女分别为53.2%和34.4%。男性和女性血清Pg抗体水平最高的五分位数分别为18.2%和25.4%。Logistic回归分析显示，血清Pg抗体水平最高的男性和hs-CRP水平较高的女性更容易发生牙周恶化。提示男性血清Pg抗体水平和女性全身炎症反应可预测牙周病的发生。

We investigated the effect of serum Porphyromonas gingivalis (Pg) antibody level and general health on periodontal disease in Japanese people. This study included 447 subjects who had the medical and dental check-up in both 2003 and 2011. Excluding the subjects with had missing date, 430 subjects (mean age 58.6 +- 11.1 years, 308 males and 122 females) were analyzed in this study. Periodontal condition was assessed by Community Periodontal Index (CPI) in 2003 and 2011. Serum Pg antibody level in 2003 was measured. Additionally, general health such as overweight, fasting glucose, high-sensitivity C-reactive protein (hs-CRP) was assessed.The percentage of the subjects with CPI code <= 3 (periodontal disease) was 47.8% (males 49.7%, females 43.4%). We defined periodontal condition indicating CPI <= 2 in 2003 and CPI <= 3in 2011 or CPI <= 3 in both 2003 and 2011 as periodontal deterioration. Males and females with periodontal deterioration were 53.2% and 34.4%, respectively. Males and females with highest quintile of serum Pg antibody level were 18.2 and 25.4%. In logistic regression analysis, males having highest quintile of serum Pg antibody level and females with higher level of hs-CRP were more likely to have periodontal deterioration. These results suggest that serum Pg antibody level in males and general inflammation in females predict the incidence of periodontal disease.