Comprehensive analysis of neural differentiation programs in the neural circuit formation

神经回路形成中神经分化程序的综合分析

• 批准号: 22500295
• 负责人: ONO Katsuhiko
• 金额: $ 2.83万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500295/
• 关键词: 転写因子; 間脳; 軸索ガイダンス分子; Olig2; Dlx2; EphA3; 視床; 腹側視床; 脊髄; 神経回路形成; 視床皮質投射; 回路形成; 軸索トレース; 細胞分化; in situ hybridization

To understand mechanisms underlying neural circuit formation, we analyzed Olig2 function on the diencephalon formation including thalamocortical projection formation. Olig2 deficient mouse shows malformation (reduced size) of the prethalamus and expansion of the thalamic eminence. In addition, thalamocortical axons follow tortuous courses. The prethalamus has long been regarded as an intermediate target for the thalamocortical projection formation. Our results indicate that Olig2 regulates prethalamus formation, and also thalamocortical projection formation with an indirect manner. These results have been submitted to Development, an international journal for developmental biology, and now under revision.

为了了解神经回路形成的机制，我们分析了Olig2在间脑形成（包括丘脑皮质投射形成）中的功能。Olig2缺陷型小鼠显示前丘脑畸形（尺寸减小）和丘脑隆起扩张。此外，丘脑皮质轴突遵循曲折的课程。长期以来，前丘脑一直被认为是丘脑皮质投射形成的中间靶点。我们的研究结果表明，Olig2调节前丘脑的形成，也丘脑皮质投射的形成与间接的方式。这些结果已提交给国际发育生物学杂志《发展》，目前正在修订中。

项目成果

Distribution of corticosteroid receptors in oligodendrocytes of mice

小鼠少突胶质细胞皮质类固醇受体的分布

• 发表时间: 2013
• 作者: MatsusueY;Horii-Hayashi N;Sasagawa T;Matsunaga W;Ono K;Nishi M
• 通讯作者: Nishi M

Generation of somatic motoneurons from Nkx2.2-expressing progenitor cells in chick embryonic spinal cord.

鸡胚脊髓中表达 Nkx2.2 的祖细胞产生体细胞运动神经元。

• 发表时间: 2012
• 作者: Kai N;Tsutsui Y;Kobayashi K;Ono K,;Gotoh H,
• 通讯作者: Gotoh H,

Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord.

• DOI: 10.1371/journal.pone.0051581
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Gotoh H;Ono K;Nomura T;Takebayashi H;Harada H;Nakamura H;Ikenaka K
• 通讯作者: Ikenaka K

Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain

• DOI: 10.1002/cne.22319
• 发表时间: 2010-06
• 期刊: Journal of Comparative Neurology
• 影响因子: 2.5
• 作者: S. Murakami;H. Ohki‐Hamazaki;Keisuke Watanabe;K. Ikenaka;K. Ono

Involvement of Olig2 in the formation of reciprocal connection between the thalamus and cortex

Olig2 参与丘脑和皮质之间相互连接的形成

• 发表时间: 2013
• 作者: Ono K;Parras CM;Nomura T;Zhang Q;Takebayashi H;Shimamura K;Gotoh H;Itohara S;Ikenaka K
• 通讯作者: Ikenaka K