A novel function of RNA in the regulation of chromatin structure

本研究的目的是通过关注RNA结合组蛋白伴侣Nucleophosmin/B23来鉴定参与染色质调控的RNA分子。我们发现B23利用其RNA结合活性被招募到rRNA基因位点上。此外，我们还阐明了B23与特定RNA靶点结合的分子机制。此外，我们还在体内鉴定了与B23特异性结合的RNA分子。本研究将有助于了解染色质结构的调控机制。

The aim of this study was to identify RNA molecules involved in chromatin regulation by focusing on RNA-binding histone chaperone Nucleophosmin/B23. We found that B23 was recruited to the rRNA gene loci by using its RNA binding activity. In addition, we clarified the molecular mechanism by which B23 binds to specific RNA target. Furthermore, we identified RNA molecules specifically bound by B23 in vivo. This study will contribute to understand the regulation mechanism of chromatin structure.