Characterization ofEcl1familygenesinvolvedinthechronological lifespan in fission yeast.

对生命周期的认识是当今生物学的重要主题之一。在这项研究中，我分析了Ecl1家族蛋白在过量生产时延长裂变酵母的时间寿命的功能。我还进行了遗传筛选，以确定参与裂变酵母按时间顺序寿命调节的新因素。因此，我成功地揭示了Ecl1的功能机制，并确定了参与裂变酵母按时间顺序寿命调节的新因素。这些结果将有助于更好地理解高等真核生物的寿命。

Understanding of lifespan is one of the important theme in current biology. In this study I analyzed the function of Ecl1 family proteins that extend chronological lifespan of fission yeast when overproduced. I also carried out genetical screening to identify novel factors involved in the regulation of chronological lifespan in fission yeast. As a consequence, I have succeeded to reveal mechanisms of Ecl1 functioning and identified novel factors that are involved in the regulation of chronological lifespan in fission yeast. These results should contribute to better understanding of lifespan in higher eukaryote.