Clarification of molecular mechanisms that are involved in development of epilepsy and anxiety.
Clarification of molecular mechanisms that are involved in development of epilepsy and anxiety.
批准号:
22580338
负责人:
KATO Keiko
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
α2,3-sialyltransferase (ST3Gal IV) is involved in developments of epilepsy, anxiety, depression, and sleep disorder. In this study, I aimed at the elucidation of the molecular mechanisms of these neuropsychiatric symptoms by using mice deficient for ST3Gal IV gene. Finally, we found that ST3Gal IV controlled the expression level of brain growth hormone that enhances progression of epileptic seizures and was associated with brain lipid metabolism system and production of steroid hormone.
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Perinatal abnormality of alpha 2, 3-sialyltransferase (ST3Gal IV) gene-deficient mice
α2, 3-唾液酸转移酶 (ST3Gal IV) 基因缺陷小鼠的围产期异常
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kato K, et al.]
通讯作者:
et al.
モデルマウスを利用した治療薬スクリーニング
使用模型小鼠进行治疗药物筛选
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[加藤啓子, 菅野拓, 平林義雄, 加藤啓子, 加藤啓子, 加藤啓子, 加藤啓子]
通讯作者:
加藤啓子
モデルマウスを利用した食品・治療薬スクリーニング法
使用模型小鼠的食品/治疗药物筛选方法
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Kato K, et al., Kato K, 加藤啓子]
通讯作者:
加藤啓子
Application of A2NTX in the treatment of refractory epilepsy.
A2NTX在难治性癫痫治疗中的应用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kato K, et al.]
通讯作者:
et al.
京都発未来創造型産業創出連携拠点
京都未来型产业创造协作基地
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[加藤啓子, 菅野拓, 平林義雄, 加藤啓子]
通讯作者:
加藤啓子
共 12 条
Clarification of molecular mechanisms that are involved in onset of epilepsy, depression, and anxiety.
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批准号:15K07774
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2015
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负责人:KATO Keiko
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依托单位:
Fundamental Studies on Prevention of Miss-swallowing for Elderly who Requires Nursing Care - Examination on time variation for co-efficient of viscosity of rice gruel during eating help -
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批准号:23660005
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:KATO Keiko
-
依托单位:
Ultrafast dynamics in solids studied by carrier-envelope phase locked laser pulses
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批准号:20750021
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$3.08万
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财政年份:2008
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负责人:KATO Keiko
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依托单位:
IDENTIFICATION AND RECOVERY OF MOLECULES IN BRAIN
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批准号:17580260
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KATO Keiko
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依托单位:
Regulation of channel activities by glycosylation during acquirement of neural plasticity
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批准号:15500260
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2003
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负责人:KATO Keiko
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依托单位:
Investigation of regulatary mechanisms of serine proteinase inhibitor, Serpinb6 against neuropsin
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批准号:13680843
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2001
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负责人:KATO Keiko
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依托单位:
海外基金