Basic study on auto-transplantation of canine bone marrow stromal cells for dogs with chronic liver disease.

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To evaluate canine BMSCs transplantation for regenerative liver therapy, we used two different models; nude mice and cyclospoline A (CSA) immunosuppressive mice for xenotransplantation. Transplanted canine BMSCs migrate effectively only into a persistently injured liver of CCl4/CSA mice, which in turn canine BMSCs may be effective to resolve inflammatory fibrosis lesions. Since cultured canine BMSCs produce matrix metalloproteinases (MMPs), therapeutic potential of canine BMSCs therapy may be associated with MMPs expression.