Uncovering the molecular mechanism of c-Myc/Max transcriptional factor complex-mediated preservation of embryonic stem cell state

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Embryonic stem (ES) cells are defined by their two remarkable properties, i.e., pluripotent and indefinite self-renewal properties. Although some papers had suggested the involvement of Myc family proteins including c-Myc protein for sustaining these prominent properties which ES cells have, this issue has never been addressed from the gene targeting analyses. Therefore, we conducted homozygous knockout of Max gene encoding an indispensable partner protein for all three Myc proteins (c-Myc, N-Myc and L-Myc) to exert their transcriptional activities as well as oncogensis promoting activities.