Clinical Assessment of Endothelial Dysfunction and Investigationof New Therapies in Cardiovascular Diseases

内皮功能障碍的临床评估和心血管疾病新疗法的研究

• 批准号: 22590786
• 负责人: SUGIYAMA Seigo
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590786/
• 关键词: 臨床心血管病態学; 血管内皮細胞障害; 冠動脈疾患; 心不全; 心血管イベント; 危険因子; 動脈硬化; 血管内皮機能; 糖尿病; vascular biology; 臨床研究; 循環器・高血圧; 血管内皮; ミトコンドリア; microparticles

We examined Reactive Hyperemia Peripheral Arterial Tonometry(RH-PAT) test and measurement of plasma levels of Endothelium-derived Microparticles(EMP) in patients suspected with coronary artery disease and heart failure patients inorder to assess vascular endothelial dysfunction clinically. We found CD144-EMP was anindependent prognostic factor for cardiovascular events in patients with heart failurewith reduced LVEF. We demonstrated the presence of coronary endothelial dysfunction andidentified distinctive clinical features in patients with coronary microvascular spasticangina. The vascular endothelial function assessed by RH-PAT test in patients with heartfailure with normal LVEF (HFNEF) was a significant and independent factor of the futurecardiovascular events. We demonstrated that the treatment by DPP-IV inhibitor(Sitagliptin); a new medicine for diabetes, improved the vascular endothelial functionand significantly inhibited atherosclerosis formation in the ApoE deficiency mouse, amouse model of atherosclerosis.

本文应用反应性充血外周动脉张力测定（RH-PAT）和血浆内皮源性微粒（EMP）检测对临床上怀疑冠心病和心力衰竭患者的血管内皮功能进行了评价。我们发现CD 144-EMP是LVEF降低的心力衰竭患者心血管事件的独立预后因素。我们证实了冠状动脉微血管痉挛性心绞痛患者存在冠状动脉内皮功能障碍，并确定了其独特的临床特征。在LVEF正常的心力衰竭患者中，用RH-PAT试验评估的血管内皮功能是未来心血管事件的重要和独立的因素。我们证明，DPP-IV抑制剂（西格列汀），一种治疗糖尿病的新药，改善血管内皮功能，显着抑制动脉粥样硬化形成的ApoE缺陷小鼠，一种小鼠模型的动脉粥样硬化。

项目成果

Digital Assessment of Peripheral Endothelial Function for the Risk Stratification in Patients With Hypertension

高血压患者风险分层的外周内皮功能数字化评估

• 发表时间: 2011
• 作者: Matsuzawa Y;Sugiyama S;Sumida H;Sugamura K;Nozaki T;Ohba K;Konishi M;Matsubara J;Akiyama E;Iwashita S;Matsui K;Umemura S;Kimura K;Ogawa H
• 通讯作者: Ogawa H

Increased Oxidative Stress in Heart Failure With Normal Left Ventricular Ejection Fraction

左心室射血分数正常的心力衰竭患者氧化应激增加

• 发表时间: 2011
• 作者: Akiyama E;Sugiyama S;Matsuzawa Y;Konishi M;Nozaki T;Ohba K;Matsubara J;Sumida H;Kaikita K;Kimura K;Umemura S;Ogawa H
• 通讯作者: Ogawa H

Impact of statin pretreatment on the incidence of plaque rupture in ST-elevation acute myocardial infarction.

他汀类药物预处理对 ST 段抬高型急性心肌梗死斑块破裂发生率的影响。

• 发表时间: 2010
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: Otsuka F;Hibi K;Kusama I;Endo M;Kosuge M;Iwahashi N;Okuda J;Tsukahara K;Ebina T;Kojima S;Sugiyama S;Ogawa H;Umemura S;Kimura K.
• 通讯作者: Kimura K.

Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improved Endothelial Function through Enhancing Action of Glucagon-like Peptide-1 in Vivo and in Vitro

二肽基肽酶 4 抑制剂 Des-Fluoro-Sitagliptin 通过增强胰高血糖素样肽 1 的体内和体外作用来改善内皮功能

• 发表时间: 2012
• 作者: Matsubara J;Sugiyama S;Nakamura T;Kurokawa H;Iwashita S;Ohba K;Maeda H;Jinnouchi H;Kim- Mitsuyama S;Ogawa H
• 通讯作者: Ogawa H

Advanced Endothelial Dysfunction in Patients with Coexistence of Coronary Artery Disease and Peripheral Artery Disease -Effect of Cilostazol on the Advanced Endothelial Dysfunction-

冠状动脉疾病和外周动脉疾病共存患者的晚期内皮功能障碍 -西洛他唑对晚期内皮功能障碍的影响 -

• 发表时间: 2012
• 作者: Kurokawa H;Sugiyama S;Matsubara J;Ohba K;Maeda H;Ogawa H;Hirofumi Maeda
• 通讯作者: Hirofumi Maeda