Function of ADRP in the pathogenesis of diabetic cardiomyopathy

ADRP在糖尿病心肌病发病机制中的作用

• 批准号: 22590972
• 负责人: SUZUKI Jinya
• 金额: $ 2.5万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590972/
• 关键词: 糖尿病性心筋症; 脂肪毒性; 脂肪滴; エネルギー代謝; 心筋症; 線維化

Function of cardiac ADRP, a lipid-droplet associated protein, was analyzed in a diabetic mouse model. Cardiac-specific ARRP-overexpressing (Tg) mice, global ADRP-KO mice (KO) and wildtype (Wt) littermates were treated with streptozotocin to induce diabetes. Despite massive lipid accumulation, systolic function was maintained in diabetic Tg mice with ameliorated diabetic gene expression profile.Packaging excess fatty acids into lipid droplets, cardiac ADRP might play a role in protecting cardiomyocytes against lipotoxicity in diabetes.

在糖尿病小鼠模型中分析了心脏ADRP（一种脂滴相关蛋白）的功能。用链脲佐菌素处理心脏特异性ARRP过表达（Tg）小鼠、整体ADRP-KO小鼠（KO）和野生型（Wt）同窝仔以诱导糖尿病。糖尿病转基因小鼠心肌细胞的脂质代谢异常，心肌细胞的收缩功能得以维持，心肌ADRP可能通过将多余的脂肪酸包装到脂滴中，对糖尿病心肌细胞的脂毒性具有保护作用。

项目成果

Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression

• DOI: 10.1016/j.bbrc.2011.03.069
• 发表时间: 2011-04-22
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takahashi, Sadao;Ito, Takashi;Shiomi, Masashi
• 通讯作者: Shiomi, Masashi

Cardiac lipid accumulation and gene expression profile in response to streptozotocin-diabetes

链脲佐菌素糖尿病引起的心脏脂质积累和基因表达谱

• 发表时间: 2012
• 作者: J. Suzuki;M. Yamada;M. Ichikawa;M. Imagawa;S. Sato;Y. Zenimaru;S. Takahashi
• 通讯作者: S. Takahashi

Comparative reactivity of remnant-like lipoprotein particles (RLP) and low-density lipoprotein (LDL) to LDL receptor and VLDL receptor: effect of a high-dose statin on VLDL receptor expression

残留样脂蛋白颗粒（RLP）和低密度脂蛋白（LDL）对LDL受体和VLDL受体的比较反应性：高剂量他汀类药物对VLDL受体表达的影响

• DOI: 10.1016/j.cca.2011.10.033
• 发表时间: 2012
• 期刊: Clin Chim Acta
• 影响因子: 5
• 作者: Mabuchi H;Nohara A;Imagawa M
• 通讯作者: Imagawa M

糖尿病に伴う心筋遺伝子発現に対するAdipose Differentiation-Related Protein(ADRP)発現の影響

脂肪分化相关蛋白（ADRP）表达对糖尿病相关心肌基因表达的影响

• 发表时间: 2012
• 作者: J. Suzuki;M. Ichikawa;S. Sato;M. Imagawa;M. Zenimaru;S. Takahashi;鈴木仁弥,市川麻衣,木村朋子,今川美智子,佐藤さつき,銭丸康夫,高橋貞夫,生山祥一郎,宮森 勇
• 通讯作者: 鈴木仁弥,市川麻衣,木村朋子,今川美智子,佐藤さつき,銭丸康夫,高橋貞夫,生山祥一郎,宮森 勇

Role of cardiac adipose differentiation-related protein (ADRP) in the pathogenesis of diabetic cardiomyopathy

心脏脂肪分化相关蛋白（ADRP）在糖尿病心肌病发病机制中的作用

• 发表时间: 2011
• 作者: J. Suzuki;M. Ichikawa;T. Kimura;M. Imagawa;S. Takahashi;I. Miyamori
• 通讯作者: I. Miyamori