Analysis of the regulatory mechanism for differentiation and functionof macrophages using a novel cytokine IL-34

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Macrophages are important hematopoietic immune cells that regulateinnate immunity, and their differentiation and function are regulated by functionalproteins called cytokines. A major cytokine identified so far is M-CSF, but it has beenrecently found that another cytokine IL-34 also regulates macrophage differentiation andfunction. In this study, we revealed that these two cytokines differentially regulatedmacrophages, suggesting that M-CSF and IL-34 have different in vivo role