Analysis of the regulatory mechanism for differentiation and functionof macrophages using a novel cytokine IL-34

新型细胞因子IL-34分析巨噬细胞分化和功能的调控机制

• 批准号: 22591041
• 负责人: SUZU Shinya
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591041/
• 关键词: マクロファージ; 分化; サイトカイン; 血液細胞分化

Macrophages are important hematopoietic immune cells that regulateinnate immunity, and their differentiation and function are regulated by functionalproteins called cytokines. A major cytokine identified so far is M-CSF, but it has beenrecently found that another cytokine IL-34 also regulates macrophage differentiation andfunction. In this study, we revealed that these two cytokines differentially regulatedmacrophages, suggesting that M-CSF and IL-34 have different in vivo role

巨噬细胞是调节先天免疫的重要造血免疫细胞，其分化和功能受到称为细胞因子的功能蛋白质的调节。目前发现的一种主要细胞因子是M-CSF，但最近发现另一种细胞因子IL-34也调节巨噬细胞的分化和功能。在本研究中，我们揭示了这两种细胞因子对巨噬细胞的差异调节，表明M-CSF和IL-34在体内具有不同的作用，

项目成果

Effects ofnaturally-arising HIV Nef mutations oncytotoxic T lymphocytes recognition andNef's functionality in primarymacrophages

自然产生的 HIV Nef 突变对细胞毒性 T 淋巴细胞识别和原代巨噬细胞中 Nef 功能的影响

• 发表时间: 2011
• 期刊: Retrovirology
• 影响因子: 3.3
• 作者: Mwimanzi P;Hasan Z;Hassan R;Suzu S,Takiguchi M;Ueno T
• 通讯作者: Ueno T

Hybridliposomes inhibit the growth ofcholangiocarcinoma by induction of cellcycle arrest in G1 phase

混合脂质体通过诱导细胞周期阻滞在G1期抑制胆管癌的生长

• 发表时间: 2010
• 期刊: Bioorganic &Medicinal Chemistry Letters
• 作者: Towata T;Komizu Y;Kariya R;Suzu S,Matsumoto Y;Kobayashi N;Wongkham C,Wongkham S;Ueoka R;Okada S
• 通讯作者: Okada S

Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma

• DOI: 10.1111/j.1349-7006.2011.01945.x
• 发表时间: 2011-07-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Komohara, Yoshihiro;Hasita, Horlad;Takeya, Motohiro
• 通讯作者: Takeya, Motohiro

HIV-1 drives differentiated macrophages toward a pro-inflammatory state

HIV-1驱动分化的巨噬细胞进入促炎状态

• 发表时间: 2011
• 作者: Imagawa J;Harada Y;Shimomura T;Tanaka H;Okikawa Y;Hyodo H;Kimura A;Harada H;Y Terada;鈴木隆浩;Shinya Suzu
• 通讯作者: Shinya Suzu

IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

• DOI: 10.1038/cdd.2010.60
• 发表时间: 2010-12-01
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Chihara, T.;Suzu, S.;Okada, S.
• 通讯作者: Okada, S.