Type I interferon and regulatory T cells associated with autoantibody production

在本研究中，我重点研究了与抗u1核糖核蛋白抗体（anti-U1RNP Abs）相关的神经精神系统性红斑狼疮（NPSLE）和肺动脉高压（PAH）。I型IFN （IFN-α/β）能刺激肺动脉内皮细胞分泌fractalkine和RANTES，而这种活性被JAK抑制剂抑制。在NPSLE中，脑脊液（CSF）中存在抗u1rnp抗体与高水平的IFN-α和MCP-1相关。

In the present study, I focused on neuropsychiatric systemic lupus erythematosus (NPSLE) and pulmonary arterial hypertension (PAH), which are associated with anti-U1 ribonucleoprotein antibodies (anti-U1RNP Abs). Type I IFN (IFN-α/β) could stimulates pulmonary arterial endothelial cells to secrete fractalkine and RANTES, that was suppressed by JAK inhibitors. In NPSLE, the presence of anti-U1RNP Abs in cerebrospinal fluid (CSF) was associated with high levels of IFN-α and MCP-1.