The mechanism of liver cancer onset in Wilson disease and its prevention

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Wilson disease (WD) causes various disorders by copper accumulationin the liver. The purpose of this study is to elucidate the onset mechanism of the liver damage including carcinogenesis in WD, and get the knowledge about its prevention. Using the model rat, it was revealed that copper accumulated and a mitochondrial disorder was induced in the liver from an early stage after birth, in addition, oxidative stress could not been controlled normally. Furthermore, the results of oxidative stress profile (OSP) analysis of the WD patient bodies suggested that a serum level of the certain fat-solubleantioxidants were decreasing, and about half of the patients are in the low active zone which means to have low antioxidant ability. These results suggested that the treatment with these antioxidants might prevent the progress of hepatic disorders including carcinogenesis in WD.