M0LECULAR MECHANISIM AND BIOMARKER OF AORTIC DISSECTION

我们评估了42例B型急性主动脉夹层（AD）患者，血清TN-C水平在第7天显著升高，然后在第28天逐渐下降到正常范围。7天血清TN-C水平与入院时c反应蛋白峰值水平、FDP水平、d -二聚体水平和主动脉夹层最大直径呈正相关。3例死亡患者入院时血清TN-C水平明显高于存活患者。血清TN-C水平在急性期显著升高，可能是预测B型急性AD患者预后的一种新的生物标志物。在小鼠模型中，TN-C在主动脉壁夹层高表达，且与α-SMA染色的血管平滑肌细胞（VSMCs）面积一致。在tnc报告基因敲入LacZ的小鼠中，主动脉壁夹层被β-gal染色，α sma阳性细胞β-gal也呈阳性。我们发现产生TN-C的细胞是主动脉壁夹层的VSMCs。

We evaluated 42 patients with type B acute aortic dissection (AD), andserum TN-C levels significantly increased at 7 days and then gradually decreased to normal range at 28 days. Serum TN-C levels at 7 days correlated positively with peak C-reactive protein levels, FDP levels, D-dimer levels, and maximum aortic diameter at the dissection level on admission. Serum TN-C levels of 3 dead patients on admission were significantly higher than those of surviving patients. Serum TN-C levels were significantly elevated during acute stage and might be a novel biomarker to predict patient prognosis of type B acute AD.In mouse model, TN-C was highly expressed in the medial layer of the dissected aortic wall, andwas concordant with the area of the vascular smooth muscle cells (VSMCs) stained by α-SMA. In the TN-C reporter mouse knock-in with LacZ, the medial layer of the dissected aortic wall was stained by the β-gal, and furthermore αSMA-positive cells were also positive in β-gal. We found that the producing cells of TN-C were VSMCs in the dissected aortic wall.