Identification of novel kinases in Wnt signaling
Identification of novel kinases in Wnt signaling
批准号:
22770127
负责人:
SATO Akira
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Wnts control various cellular functions including proliferation, differentiation, death, migration, and polarity, by activating multiple intracellular signaling cascades including the.β-catenin-dependent and-independent pathways. Dishevelled(Dvl), which has multiple phosphorylation sites, is an essential intracellular component for both pathways. However, the detailed mechanisms and regulations of Wnt signaling cascades through Dvl have still been poorly understood. In this study, I performed siRNA library screenings to identify novel kinases that phosphorylate Dvl.
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Wnt5a inhibits the Wnt/β-catenin pathway by binding to Frizzled2.
Wnt5a 通过与 Frizzled2 结合来抑制 Wnt/β-catenin 通路。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ryo Kitahara, Akiko Tanji, Souichirou Kitazawa, Yoshihiro Taniguchi, 佐藤朗]
通讯作者:
佐藤朗
Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloprotainase
Wnt5a 信号传导参与前列腺癌的侵袭性和金属蛋白酶的表达
DOI:
--
发表时间:
2010
期刊:
Oncogene
影响因子:
8
作者:
[Yamamoto H., Oue N., Sato A., Hasegawa Y., Yamamoto H., Matsubara A., Yasui W, and Kikuchi A.]
通讯作者:
and Kikuchi A.
DOI:
10.1242/jcs.091876
发表时间:
2012-01-15
期刊:
JOURNAL OF CELL SCIENCE
影响因子:
4
作者:
[Sakane, Hiroshi, Yamamoto, Hideki, Kikuchi, Akira]
通讯作者:
Kikuchi, Akira
DOI:
10.1158/1535-7163.mct-11-0682
发表时间:
2012-02-01
期刊:
MOLECULAR CANCER THERAPEUTICS
影响因子:
5.7
作者:
[Hanaki, Hideaki, Yamamoto, Hideki, Kikuchi, Akira]
通讯作者:
Kikuchi, Akira
DOI:
10.1016/j.ydbio.2010.11.034
发表时间:
2011-02-15
期刊:
DEVELOPMENTAL BIOLOGY
影响因子:
2.7
作者:
[Liu, Wei, Su, Li-Ting, Runnels, Loren W.]
通讯作者:
Runnels, Loren W.
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