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Comparison between concentration of I type collagen C-terminal telopeptide (ICTP) in the synovial fluid and semi-quantified ^<99m>Tc-MDP accumulation of the temporpmandibular joint in the tempromandibular joint disorders (TMD).

颞下颌关节疾病(TMD)中滑液中I型胶原C末端端肽(ICTP)浓度与颞下颌关节半定量^<99m>Tc-MDP积累的比较。

基本信息

批准号：
09672072
负责人：
SATO Akira
金额：
$ 1.86万
依托单位：
NIPPON DENTAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

We investigated the relationship between clinical outcome of arthrocentesis in temporomandibular joint >sorders and the concentration of the bone metabolic marker, ICTP (type I collagen C-terminal telopeptide), in the synovial fluid. The purpose of this study is to evaluate the predictability of ICTP for outcome of arthrocentesis. Materials and Methods : Twenty-four patients with TMJ disorders (mean age ; 42.1*20.1 years, range in age from 14 to 86) undergoing arthrocentesis and sodium hyaluronate injection of TMJs were enrolled in this study between October 1997 and August 1998.Sixteen TMJs of 14 patients were clinically diagnosed internal derangements (ID) and 10 TMJs of 10 patients were diagnosed osteoarthrosis (QA). Synovial fluid was obtain from 26 joints at the time of arthrocentesis.The concentration of ICTP was measured using ICTP radio immunoassay. Result : The mean preoperative maximum incisal opening (MIG) was 33.5 11.1 mm. About one month after the procedure, MIG increased (43.0 *6.2mm), and pain disappeared or decreased in all patients. There was no significant difference in ICTP concentration of the synovial fluid between patients with GA (2.6*2.8 ng/ml) and ID (2.42.2 ng/ml). However, the mean concentration of ICTP from poor responders (MIO<40.Omm at the time about one month after the procedure) was higher (3.8*3.3 ng/ml) than those (2.2*2.1 ng/ml) of good responders (MIO*4O.O mm). Conclusion : The results of this study indicate that ICTP concentration may be an efficient predictor for the outcome of arthrocentesis.

我们研究了颞下颌关节>级关节穿刺的临床结果与滑液中骨代谢标志物ICTP （I型胶原c端末端肽）的浓度之间的关系。本研究的目的是评估ICTP对关节置换术结果的可预测性。材料与方法：1997年10月至1998年8月，选取24例颞下颌关节病变患者，平均年龄42.1*20.1岁，年龄14 ~ 86岁，行关节穿刺加透明质酸钠注射治疗。14例患者中16例TMJs临床诊断为内部紊乱（ID）， 10例患者中10例TMJs临床诊断为骨关节病（QA）。在关节穿刺时从26个关节获得滑液。采用ICTP放射免疫法测定ICTP浓度。结果：平均术前最大切牙开口（MIG）为33.5 11.1 mm。术后1个月左右，所有患者MIG均升高（43.0 *6.2mm），疼痛消失或减轻。GA组与ID组滑膜液ICTP浓度（2.6*2.8 ng/ml）与ID组（2.42.2 ng/ml）差异无统计学意义。然而，不良反应者的ICTP平均浓度(MIO<40。在手术后大约一个月的时间内，Omm （3.8*3.3 ng/ml）高于良好应答者（MIO* 40o）（2.2*2.1 ng/ml）。O毫米)。结论：本研究结果表明，ICTP浓度可能是关节穿刺结果的有效预测因子。