Characterization of a novel modulator of Wnt signaling
Characterization of a novel modulator of Wnt signaling
批准号:
20770179
负责人:
SATO Akira
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Wnt signaling pathway play important roles in many developmental processes in animals. I identified a new modulator of the Wnt/β-catenin pathway, named DBP, to negatively control this pathway via binding to Dvl. In addition, it was found that Wnt5a, a member of 19 Wnts, inhibits Wnt3a-dependent activation of the Wnt/β-catenin pathway by competing with Wnt3a for binding to the Wnt receptor Frizzled 2.
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Wnt5aによるWnt3a- β-catenin経路の新規抑制機構の解析
Wnt5a 对 Wnt3a-β-catenin 通路的新型抑制机制分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kikuchi A, Yamamoto H, Sato A, Kikuchi A, 菊池章, 佐藤朗, 佐藤朗, 佐藤朗]
通讯作者:
佐藤朗
Wntによるβカテニン非依存性経路の活性化とその異常による病態
Wnt对β-catenin非依赖性通路的激活及其异常引起的病理状况
DOI:
--
发表时间:
2009
期刊:
蛋白質核酸酵素(PNE) 54
影响因子:
--
作者:
[Kikuchi A, Yamamoto H, Sato A, Kikuchi A, 菊池章]
通讯作者:
菊池章
DOI:
10.1038/onc.2009.496
发表时间:
2010-04-08
期刊:
ONCOGENE
影响因子:
8
作者:
[Yamamoto, H., Oue, N., Kikuchi, A.]
通讯作者:
Kikuchi, A.
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[A. Sato;Hideki Yamamoto;H. Sakane;H. Koyama;A. Kikuchi]
通讯作者:
A. Sato;Hideki Yamamoto;H. Sakane;H. Koyama;A. Kikuchi
Wnt5a regulates distinct signaing pathways by binding to Frizzled2
Wnt5a 通过与 Frizzled2 结合来调节不同的信号通路
DOI:
--
发表时间:
2010
期刊:
EMBO J 29
影响因子:
--
作者:
[Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A]
通讯作者:
Kikuchi A
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Non-invasive diagnostic method for atherosclerotic lesious
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Comparative Educational Research on Personnel Administration of Public School Teachers
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pathophysiological study of fetal distress using chronic preparation in sheep
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