Molecular mechanisms in two cell death-types, necrosis and apoptosis, induced by 5-fluoro-2'-deoxyuridine
Molecular mechanisms in two cell death-types, necrosis and apoptosis, induced by 5-fluoro-2'-deoxyuridine
批准号:
21790078
负责人:
SATO Akira
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
我们研究了这种抗肿瘤药物诱导的细胞坏死和凋亡的细胞死亡机制。我们发现,核内膜蛋白层粘连蛋白B1,细胞质中间体的毒性蛋白细胞角蛋白-19,和转录因子可能有关键作用,在调节细胞死亡形态。
英文摘要
We have investigated the cell-death mechanisms of necrosis and apoptosis induced by this anti-tumor drug. We found that the nuclear inner membrane protein lamin-B1, the cytoplasmic intermediate filament-protein cytokeratin-19, and the transcription factor may have key roles in regulating cell-death morphology.
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Protein expression profiles of necrosis and apoptosis induced by 5-fluoro-2'-deoxyuridine in mouse cancer cells.
5-氟-2-脱氧尿苷诱导小鼠癌细胞坏死和凋亡的蛋白表达谱。
DOI:
--
发表时间:
2010
期刊:
Journal of Proteome Research 9
影响因子:
--
作者:
[Sato A., Satake A., Hiramoto A., Wataya Y., Kim H.-S.]
通讯作者:
Kim H.-S.
Association of intermediate filament proteins with necrosis and apoptosis in cell death induced by 5-fluoro-2'-deoxyuridine.
中间丝蛋白与 5-氟-2-脱氧尿苷诱导的细胞死亡中的坏死和凋亡的关联。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Akira Sato, Kentaro Nakama, Akihiro Yamamoto, Akiko Hiramoto, Hye-Sook Kim, Yusuke Wataya]
通讯作者:
Yusuke Wataya
新規抗腫瘍ヌクレオシドアナログ1-(3-C-ethynyl-b-D-ribo-pentofuranosyl)cytosine(ECyd, TAS-106)によるアポトーシス誘導機構の解明
新型抗肿瘤核苷类似物 1-(3-C-乙炔基-b-D-核糖-呋喃戊糖基)胞嘧啶 (ECyd, TAS-106) 阐明细胞凋亡诱导机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[綿矢有佑, 平本晃子, 佐藤聡, 金惠淑]
通讯作者:
金惠淑
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Molecular mechanisms of apoptosis induced by 3'-ethynylcytidine.
3-乙炔胞苷诱导细胞凋亡的分子机制。
DOI:
--
发表时间:
2009
期刊:
Nucleic Acids Symposium Series 53
影响因子:
--
作者:
[Wataya Y., Naito T., Sato A., Hiramoto A., Kitade Y., Sasaki T., Matsuda A., Fukushima M., Kim H.-S.]
通讯作者:
Kim H.-S.
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A Study on the development of structure for mutual learning and support in the area to encourage proactive social participation among elderly with special needs.
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批准号:15K03952
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.08万
-
财政年份:2015
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负责人:SATO Akira
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依托单位:
Development of the macro-micro fluid and fracture evaluation methods by hybrid X-ray CT method.
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批准号:23560987
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:SATO Akira
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依托单位:
Identification of novel kinases in Wnt signaling
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批准号:22770127
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2010
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负责人:SATO Akira
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依托单位:
M0LECULAR MECHANISIM AND BIOMARKER OF AORTIC DISSECTION
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批准号:22591535
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2010
-
负责人:SATO Akira
-
依托单位:
Characterization of a novel modulator of Wnt signaling
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批准号:20770179
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2008
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负责人:SATO Akira
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依托单位:
Accelerated thrombus organization in the swine abdominal aortic aneurysm model
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批准号:20591511
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:SATO Akira
-
依托单位:
Analysis of Migration Process of Super Critical CO2 in the rock by means of X-ray CT
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批准号:19760587
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.16万
-
财政年份:2007
-
负责人:SATO Akira
-
依托单位:
A Study on Muon Ionization Cooling in a Ring
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批准号:18340065
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.39万
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财政年份:2006
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负责人:SATO Akira
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依托单位:
Inhibitory effects of basic fibroblast growth factor incorporated into bioabsorbable polymer sponge sheet on the progression of experimental abdominal aortic aneurysms
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批准号:18591402
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:SATO Akira
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依托单位:
A new sutureless vascular anastomotic technique using the bioabsorbable polymer and the stainless steel plate with the minute projections
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批准号:15591322
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:SATO Akira
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依托单位:
The effects of extracorporeal membrane oxygenation on hypoxic fetal lambs
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批准号:11470351
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
-
财政年份:1999
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负责人:SATO Akira
-
依托单位:
Effects of Locally Applied Transdermal Nitroglycerin for the Treatment of Chronic Limb Ischemia
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批准号:10671091
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1998
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负责人:SATO Akira
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依托单位:
Comparison between concentration of I type collagen C-terminal telopeptide (ICTP) in the synovial fluid and semi-quantified ^<99m>Tc-MDP accumulation of the temporpmandibular joint in the tempromandibular joint disorders (TMD).
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批准号:09672072
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
-
财政年份:1997
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负责人:SATO Akira
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依托单位:
Current Situation of the Upper Secondary School Students' Competence for Decision of Their Future Way of Life and the Teacher's Effect
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批准号:09410080
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$2.75万
-
财政年份:1997
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负责人:SATO Akira
-
依托单位:
The prolongation of xenograft survival with human natural xenoantibody elimination
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批准号:08671327
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
-
财政年份:1996
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负责人:SATO Akira
-
依托单位:
Non-invasive diagnostic method for atherosclerotic lesious
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批准号:07507008
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$5.12万
-
财政年份:1995
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负责人:SATO Akira
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依托单位:
The Co-operative Research on Improvement of Curriculum-Planning and Crediting in Senior High Schools
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批准号:04306017
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$0.0万
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财政年份:1992
-
负责人:SATO Akira
-
依托单位:
Comparative Educational Research on Personnel Administration of Public School Teachers
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批准号:01301036
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项目类别:Grant-in-Aid for Co-operative Research (A)
-
资助金额:$3.39万
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财政年份:1989
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负责人:SATO Akira
-
依托单位:
pathophysiological study of fetal distress using chronic preparation in sheep
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批准号:01480396
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1989
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负责人:SATO Akira
-
依托单位:
海外基金