Regulation of oncogenes or tumor suppressor genes in Urological cancer by micro RNA

miR-199a和miR-101在肾细胞癌（RCC）中表达被抑制，其强制表达导致GSK3β和EZH2的抑制，从而降低癌细胞的增殖。重新引入miR-199a和/或miR-101可能是一种有益的治疗策略。ATBF1的表达降低与RCC的恶性倾向相关。hsa-miR-203, hsa-miR-194， hsa-miR-204被认为是ATBF1的抑制因子，可能是另一种新的治疗方式的新靶点。

Enforced expressions of miR-199a and miR-101, of which expressions are inhibited in renal cell cancer (RCC), leads to suppression of GSK3β and EZH2 resulting in reducing cancer cell proliferation. Re-introduction of miR-199a and/or miR-101 might be a beneficial treatment strategy. Reduced expression of ATBF1 is correlated with more malignant character of RCC. hsa-miR-203, hsa-miR-194, hsa-miR-204 are proposed as suppressors of ATBF1 might be novel targets for another new treatment modality.