Dissecting the Factors Involved in the Locomotion Mode of Neuronal Migration in the Developing Cerebral Cortex

剖析发育中大脑皮层神经元迁移运动模式所涉及的因素

• 批准号: 22790998
• 负责人: NISHIMURA Yoshiaki
• 金额: $ 2.58万
• 依托单位: Doshisha University (2011-2012)Institute for Developmental Research, Aichi Human Service Center (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790998/
• 关键词: 発達小児科学; 大脳皮質形成; 神経細胞移動; ロコモーション移動; スライス培養

Neuronal migration is essential for proper cortical layer formation, as migration defects result in neurological disorders. The locomotion mode of neuronal migration covers most of the migration route and thereby is the main contributor to cortical layer formation. However, analysis of the molecular mechanisms regulating this mode is difficult. In this study, we used an ex vivo chemical inhibitor screening, allowing us to directly analyze the locomotion mode of migration, and found several regulatory molecules regurating the locomotion mode.

神经元迁移对于适当的皮质层形成是必不可少的，因为迁移缺陷会导致神经系统疾病。神经元迁移的运动模式涵盖了大部分的迁移路线，从而是皮质层形成的主要贡献者。然而，分析调节这种模式的分子机制是困难的。在这项研究中，我们使用了离体化学抑制剂筛选，使我们能够直接分析迁移的运动模式，并发现了几个调节分子重新调节运动模式。

项目成果

Neurovascular interaction in the developing neocortex

发育中的新皮质中的神经血管相互作用

• 发表时间: 2012
• 作者: Yoshiaki V. Nishimura;Yutaka Inaguma;Masatsugu Ema;Mitsuharu Hattori;Koh-ichi Nagata;Ken-ichi Mizutani
• 通讯作者: Ken-ichi Mizutani

Angiogenesis in the developing cerebral cortex

发育中的大脑皮层的血管生成

• 发表时间: 2011
• 作者: Yoshiaki V. Nishimura;Yutaka Inaguma;Ayako Taguchi;Hidenori Ito and Koh-ichi Nagata
• 通讯作者: Hidenori Ito and Koh-ichi Nagata

Cdk5 plays multiple roles in cortical neuronal migration and morphological changes

Cdk5 在皮质神经元迁移和形态变化中发挥多种作用

• 发表时间: 2012
• 作者: Takeshi Kawauchi;Yoshiaki V. Nishimura;Mima Shikanai;Koh-ichi Nagata;and Kazunori Nakajima
• 通讯作者: and Kazunori Nakajima

Regulation of radial migration of cortical pyramidal neurons by a Ca2+/calmodulin-dependent protein kinase I cascade

Ca2/钙调蛋白依赖性蛋白激酶 I 级联调节皮质锥体神经元的径向迁移

• 发表时间: 2011
• 作者: Shin-ichiro Horigame;Sayaka Takemoto-Kimura;Aki Adachi-Morishima;Natsumi Ageta-Ishihara;Kanzo Suzuki;Mio Nonaka;Michiko Okamura;Yoshiaki V. Nishimura;Takeshi Kawauchi;Kazunori Nakajima;Hiroyuki Okuno;Haruhiko Bito
• 通讯作者: Haruhiko Bito

Dissecting the Factors Involved in the Locomotion Mode of Neuronal Migration in the Developing Cerebral Cortex

• DOI: 10.1074/jbc.m109.033761
• 发表时间: 2010-02-19
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Nishimura, Yoshiaki V.;Sekine, Katsutoshi;Kawauchi, Takeshi
• 通讯作者: Kawauchi, Takeshi