The role of Th17 and Th22 in the development of atopic dermatitis
The role of Th17 and Th22 in the development of atopic dermatitis
批准号:
22791068
负责人:
HONDA Tetsuya
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
采用小鼠AD模型,探讨IL-17在异位性皮炎(AD)发生中的作用。将IL-17缺陷小鼠应用于模型,临床症状减轻,血清中抗原特异性IgE水平降低。在皮肤中,IL-17不仅由Th17细胞产生,也由γ - δ T细胞产生。这些结果提示IL-17在AD的建立中发挥了重要作用。
英文摘要
The role of IL-17 in the development of atopic dermatitis(AD) was investigated using mouse AD model. IL-17 deficient mice were applied to the model, and showed reduced clinical symptoms and antigen-specific IgE level in the serum. In the skin IL-17 was produced not only from Th17 cells but also gamma-delta T cells. These results suggest that IL-17 play important role in the establishment of AD.
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专著(0)
科研奖励(0)
会议论文
The role of regulatory T cells in contact hypersensitivity
调节性 T 细胞在接触性超敏反应中的作用
DOI:
--
发表时间:
2010
期刊:
Recent Patent Inflammation and Allergy Drug Discovery
影响因子:
--
作者:
[Honda T, Yoshiki Miyachi, Kenji Kabashima]
通讯作者:
Kenji Kabashima
The role of regulatory T cells in the sensitization phase of mouse contact hypersensitivity
调节性T细胞在小鼠接触超敏反应致敏阶段的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Honda T, Yoshiki Miyachi, Kenji Kabashima]
通讯作者:
Kenji Kabashima
DOI:
10.1073/pnas.1018625108
发表时间:
2011-04-19
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Soontrapa, Kitipong, Honda, Tetsuya, Narumiya, Shuh]
通讯作者:
Narumiya, Shuh
Live imaging analysis of cutaneous immune responses
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批准号:24591650
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2012
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负责人:HONDA Tetsuya
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依托单位:
Prostaglandin E(2)-EP3 signaling suppress skin inflammation in mouse contact hypersensitivity.
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批准号:20790798
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:HONDA Tetsuya
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依托单位:
海外基金