Developments of the quantitative imaging methods for bio-functions with MRI

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In this project, the developments of the molecular MR probes were aimed for quantitative analysis of bio-functions. By using the perfluorinated dendrimers as 19F MR probes, several detection systems were established. In addition, the applicability of the probes for the tumor detection was also investigated. Initially, the nanoparticle-based probes were prepared with the target-responsive molecular-releasing mechanism. Consequently, the bimodal evaluation for the enzymatic activity was accomplished using the synthetic probes. Next, to present the practical demonstration, the 19F MR probes for monitoring the glutathione reductase activity were prepared. Finally, the quantitative detection of the target enzyme can be achieved. These results indicate that the purposes of this project can be fully accomplished.