Developments of the quantitative imaging methods for bio-functions with MRI

MRI生物功能定量成像方法的进展

• 批准号: 22750107
• 负责人: TANAKA Kazuo
• 金额: $ 2.58万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22750107/
• 关键词: 分子プローブ; 19F MRI; 癌診断; MRI; POSS; デンドリマー; ナノ微粒子; がん診断

In this project, the developments of the molecular MR probes were aimed for quantitative analysis of bio-functions. By using the perfluorinated dendrimers as 19F MR probes, several detection systems were established. In addition, the applicability of the probes for the tumor detection was also investigated. Initially, the nanoparticle-based probes were prepared with the target-responsive molecular-releasing mechanism. Consequently, the bimodal evaluation for the enzymatic activity was accomplished using the synthetic probes. Next, to present the practical demonstration, the 19F MR probes for monitoring the glutathione reductase activity were prepared. Finally, the quantitative detection of the target enzyme can be achieved. These results indicate that the purposes of this project can be fully accomplished.

在该项目中，分子MR探针的发展旨在定量生物功能分析。通过将全氟的树枝状聚合物作为19F MR探针，建立了几个检测系统。另外，还研究了探针检测的探针的适用性。最初，用靶反应分子释放机制制备了基于纳米颗粒的探针。因此，使用合成探针完成了酶活性的双峰评估。接下来，为了介绍实际的演示，准备了19F MR探针，以监测谷胱甘肽还原酶活性。最后，可以实现目标酶的定量检测。这些结果表明该项目的目的可以完全完成。

项目成果

Side-Chain Effect of Octa-Substituted POSS Fillers on Refraction in Polymer Composites

八取代 POSS 填料对聚合物复合材料折射的侧链效应

• DOI: 10.1002/pola.24370
• 发表时间: 2010
• 期刊: J. Polym. Sci. Part A : Polym. Chem
• 作者: Tanaka;K.; Adachi;S.; Chujo;Y.
• 通讯作者: Y.

光化学の事典、ポリエンの光化学

光化学百科全书，多烯光化学

• 发表时间: 2012
• 作者: 田中一生;他
• 通讯作者: 他

高分子薄膜の低屈折率化におけるPOSSフィラーの置換基効果

POSS填料降低聚合物薄膜折射率的取代效应

• 发表时间: 2010
• 作者: 加藤和明;伊藤耕三;尾西尚弥・塩月雅士・三田文雄・青木俊樹・増田俊夫;田中一生・足立茂寛・安田則彦・中條善樹
• 通讯作者: 田中一生・足立茂寛・安田則彦・中條善樹

rsonic Acid-Presenting Super paramagnetic Iron Oxide for pH-Responsive Aggregation under Slight Acidic Conditions

具有酸性的超顺磁性氧化铁，可在弱酸性条件下实现 pH 响应性聚集

• DOI: 10.1016/j.bmc.2011.02.027
• 发表时间: 2011
• 期刊: Bioorg. Med. Chem
• 作者: Minehara;H.; Naka;K.; Tanaka;K.; Narita;A.; Chujo;Y.
• 通讯作者: Y.

Construction of MRI contrast agents using nanobuilding blocks,dendrimers,polymers,and nanoparticles,for the quantitative analysis of biological events

使用纳米构件、树枝状聚合物、聚合物和纳米颗粒构建 MRI 造影剂，用于生物事件的定量分析

• 发表时间: 2010
• 作者: Kazuo Tanaka;Yoshiki Chujo
• 通讯作者: Yoshiki Chujo