Elucidation of molecular basis of specificity in biosynthetic regulation and action mechanisms of antimicrobial peptides from lactic acid bacteria

对来自乳酸菌的抗菌肽细菌素的结构进行了分析，并鉴定了一些新型细菌素，如肠菌素 W、白环素 Q 和白环菌素 YM。对乳酸菌素Q、肠菌素NKR-5-3、威瑟菌素YM等细菌素的生物合成基因及其功能进行了分析，部分阐明了它们的生物合成调控系统。研究了一些细菌素的作用机制，并揭示了其特定抗菌作用的一些因素。

Structures of antimicrobial peptides, bacteriocins, from lactic acid bacteria were analyzed, and some novel bacteriocins such as enterocin W, leucocyclicin Q and weissellicins YM were identified. Biosynthetic genes and their functions of some bacteriocins such as lacticin Q, enterocins NKR-5-3 and weissellicins YM were analyzed, and their biosynthetic regulation systems were partly unraveled. Action mechanisms of some bacteriocins were studied, and some factors for their specific antimicrobial actions were revealed.