Elucidation of molecular basis of specific action mechanisms of antimicrobial peptides from lactic acid bacteria

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The structures of various novel antimicrobial peptides, bacteriocins, from lactic acid bacteria were determined. One of the novel bacteriocins, lactocyclicin Q, is a cyclic peptide whose N- and C-terminals are bound with a peptide bond. Lacticin Q exerts antimicrobial activity via huge pore formation on bacterial cell membrane that causes leakage of cellular components such as ATP and small proteins. Since the actions of lacticin Q and lipids accords with the characteristics of Toroidal Pore model, the action mechanism of lacticin Q was termed Huge Toroidal Pore model .