The role of surfactant protein A in lung cancer progression and metastasis.

表面活性蛋白A在肺癌进展和转移中的作用。

• 批准号: 22790759
• 负责人: GOTO Hisatsugu
• 金额: $ 2.41万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790759/
• 关键词: 肺がん; サーファクタント; 肺サーファクタント蛋白

Human SP-A gene was introduced into the human lung adenocarcinoma cell line, and in vivo effect of SP-A over-expression on cancer progression was examined in experimental mouse model. Lung tumor produced by SP-A over-expression cells had ; 1. less tumor burden and pleural effusion, 2. increased number of infiltrated macrophages, 3. increased number of M1 macrophages(anti-tumor macrophages). SP-A may have a protective role in lung cancer progression through modulating host immune response.

将人SP-A基因导入人肺腺癌细胞系，并在实验小鼠模型中检查SP-A过表达对癌症进展的体内作用。SP-A过表达细胞产生的肺肿瘤有; 1.减少肿瘤负荷和胸腔积液，2.浸润的巨噬细胞数量增加，3. M1巨噬细胞（抗肿瘤巨噬细胞）数量增加。SP-A可能通过调节宿主免疫反应而对肺癌的发展起保护作用。

项目成果

The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice.

• DOI: 10.1007/s00280-010-1503-x
• 发表时间: 2011-08
• 期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY
• 影响因子: 3
• 作者: Trung The Van;Hanibuchi, Masaki;Kakiuchi, Soji;Sato, Seidai;Kuramoto, Takuya;Goto, Hisatsugu;Mitsuhashi, Atsushi;Nishioka, Yasuhiko;Akiyama, Shin-ichi;Sone, Saburo
• 通讯作者: Sone, Saburo

Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice

• DOI: 10.1007/s10585-010-9333-0
• 发表时间: 2010-05
• 期刊: Clinical & Experimental Metastasis
• 影响因子: 4
• 作者: Satoshi Sakaguchi;H. Goto;M. Hanibuchi;Shinsaku Otsuka;H. Ogino;S. Kakiuchi;H. Uehara;S. Yano;Y. Nishioka;S. Sone

Investigation of the outpatient chemotherapy for lung cancer patients in Tokushima University Hospital.

德岛大学附属医院肺癌门诊化疗情况调查

• DOI: 10.2152/jmi.58.219
• 发表时间: 2011
• 期刊: The journal of medical investigation : JMI
• 作者: H. Goto;M. Hanibuchi;Satoshi Sakaguchi;T. Kanematsu;S. Kakiuchi;Hideki Tomimoto;M. Azuma;Toshifumi Tezuka;H. Tada;Y. Miki;Toshimi Nakamura;S. Sone;Y. Nishioka
• 通讯作者: Y. Nishioka

Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model.

表面活性剂蛋白 A 在实验性肺转移模型中抑制人肺腺癌的进展。

• 作者: Hisatsugu Goto;et al.
• 通讯作者: et al.

Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response.

表面活性剂蛋白 A 通过调节宿主免疫反应抑制裸鼠人肺腺癌的进展。

• 作者: Atsushi Mitsuhashi;et al.
• 通讯作者: et al.