A role of Wnt/beta-catenin signal network on the stimulated bone formation under mechanical stress.

Wnt/β-连环蛋白信号网络对机械应力下刺激骨形成的作用。

• 批准号: 22592036
• 负责人: IKEGAME Mika
• 金额: $ 2.5万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592036/
• 关键词: 骨形成・機械的刺激; 局所因子; サイトカイン; 骨縫合部組織; Wnt; 骨形成; 機械的刺激; BMP; 骨芽細胞; 網羅的遺伝子解析; βカテニン

We can stimulate bone formation with tensile stress on a suture of mouse calvaria. Gene expressions of many factors, especially Wnt/beta-catenin family which are involved in bone-cell activity were examined during the stimulated bone formation. We could show the relative expression ratios of some factors at each time point of the experiment. Those results suggested which factors were more important at each stage of the stimulated bone formation.

我们可以通过对小鼠颅骨缝合处施加张应力来刺激骨形成。在刺激骨形成过程中，检测了许多因子的基因表达，特别是Wnt/β-catenin家族，其参与骨细胞活性。我们可以显示在实验的每个时间点的一些因素的相对表达率。这些结果表明，在刺激骨形成的每个阶段，哪些因素更重要。

项目成果

A comprehensive analysis of mechanical stress-regulated gene expression in mouse cranial sutures

小鼠颅骨缝机械应力调节基因表达的综合分析

• 发表时间: 2013
• 作者: Mika Ikegame (代 表);Mariko Kawai;Yoshiaki Tabuchi;Yukihiro Furusawa;Takashi Kondo;Masaki Nakano;Atsuhiko Hattori and Toshio Yamamoto
• 通讯作者: Atsuhiko Hattori and Toshio Yamamoto