The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer
The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer
批准号:
22592046
负责人:
SASAKI Minoru
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
牙菌斑中存在血管紧张素链球菌,口腔粘膜中的血管紧张素链球菌感染可能与某些鳞癌密切相关。本研究克隆了钩端螺旋体纤维连接蛋白结合蛋白基因fbp62,并探讨了该基因在钩端螺旋体感染中的致病作用。结果表明,斑点链球菌fbp62基因敲除突变株(Dfbp62)与黏膜上皮细胞的黏附能力显著降低,感染Dfbp62的小鼠死亡率和脓肿形成率明显低于野生型斑点链霉菌感染小鼠。因此,一种新的血管紧张链球菌纤维连接蛋白结合蛋白Fbp62可能成为治疗血管紧张链球菌相关口腔癌的有效候选疫苗。
英文摘要
Streptococcus anginosus inhabits dental plaques, and its infection in oral mucosa could be closely related with some squamous cell carcinoma. In this study for the development of vaccine, the fibronectin binding protein gene of S. anginosus, designated fbp62 was cloned, and the pathogenic involvement of Fbp62 in S. anginosusinfection was investigated. The results indicated that the adhesive ability of an fbp62knockout mutan t (Dfbp62) of S. anginosus to mucosal epithelial cells diminished significantly, and that the Dfbp62-infected mice showed considerably lower mortality and abscess formation rates, compared to the wild type S. anginosus-infected mice. Thus, a novel fibronectin binding protein of S. anginosus, Fbp62, could be an effective vaccine candidate for the S. anginosus-related oral cancer.
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Macrophage reaction against sub-micron titanium particles
巨噬细胞对亚微米钛颗粒的反应
DOI:
10.1007/978-4-431-54070-0_84
发表时间:
2012
期刊:
Interface Oral Health Science 2011
影响因子:
--
作者:
[Taira, M., Sasaki, M. and Kimura, S.]
通讯作者:
S.
Nutritionally variant streptococciの新規迅速同定法
营养变异链球菌快速鉴定新方法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[下山佑, 佐々木実, 石河太知, 木村重信]
通讯作者:
木村重信
Auto-catalytic propeptide processing facilitates the final hetero-catalytic maturation of glutamyl endopeptidase GluV8
自催化前肽加工促进谷氨酰内肽酶 GluV8 最终异质催化成熟
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ohara-Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S., Ono, T. and Nemoto, T.K]
通讯作者:
T.K
Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions
暴露于低细胞毒性 IC90 铜 (2 ) 离子的人类巨噬细胞的蛋白质组分析
DOI:
10.4012/dmj.2010-088
发表时间:
2011
期刊:
Dental Materials Journal
影响因子:
2.5
作者:
[Taira, M., 他6名]
通讯作者:
他6名
Structural chemistry of Staphylo coccus aureus glutamyl endopeptidase.
金黄色葡萄球菌谷氨酰内肽酶的结构化学。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ohara -Nemoto, Y., Rouf, S.M.A., Shimoyama, Y., Kimura, S. and Nemoto, T.K.]
通讯作者:
T.K.
共 36 条
Research on method of extracting collocation for each word sense and its application for word sense disambiguation
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批准号:24700131
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.33万
-
财政年份:2012
-
负责人:SASAKI Minoru
-
依托单位:
Development of Wearable Respiratory Sensor and Practical Application
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批准号:24650397
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2012
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负责人:SASAKI Minoru
-
依托单位:
Highly sensitive infra-red sensor using non-linear vibration
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批准号:21656105
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$1.72万
-
财政年份:2009
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负责人:SASAKI Minoru
-
依托单位:
A study of self-sensing control of hydrophilic electrolytic polymer actuator
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批准号:20560235
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2008
-
负责人:SASAKI Minoru
-
依托单位:
Stabilized Temperature Characteristics, High-Speed Response, and Low-Voltage Driving of Micromirror
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批准号:19016003
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$5.44万
-
财政年份:2007
-
负责人:SASAKI Minoru
-
依托单位:
High-performance MEMS devices realized by three-dimensional photolithography
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批准号:18681023
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$16.39万
-
财政年份:2006
-
负责人:SASAKI Minoru
-
依托单位:
Control of a Micro-Actuator for the Hard Disk Drive using Self-Sensing Actuation
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批准号:17560224
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2005
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负责人:SASAKI Minoru
-
依托单位:
Using senescence-accelerated mouse (SAM) strains and aged C57/BL/6 mice, we examined the senescence-related changes of mucosal immune responses.
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批准号:14571744
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
-
财政年份:2002
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负责人:SASAKI Minoru
-
依托单位:
Development of integrated optical measurement systems having layered structures
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批准号:12555112
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$2.62万
-
财政年份:2000
-
负责人:SASAKI Minoru
-
依托单位:
Tele-operation of Flexible Manipulator by using Bio-potential Signals
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批准号:12650247
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2000
-
负责人:SASAKI Minoru
-
依托单位:
Imaging Sectroscopy of planetary nabula with microlens array spectrogrph.
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批准号:11640239
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1999
-
负责人:SASAKI Minoru
-
依托单位:
DEVELOPMENT OF TRANSIENT THERMOELECTRIC EFFECT IN HIGH MAGNETIC AND ELECTRIC FIELDS AND ITS APPLICATION TO THE STUDY OF CHARGE DENSITY WAVE MATERIALS
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批准号:09450037
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.82万
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财政年份:1997
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负责人:SASAKI Minoru
-
依托单位:
DEVELOPMENT OF CONDUCTION CARRIER SPECTROSCOPY AND ITS APPLICATION TO THE STUDY OF HIGH TEMPERATURE SUPERCONDUCTORS
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批准号:06452140
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.94万
-
财政年份:1994
-
负责人:SASAKI Minoru
-
依托单位:
Development of a Neural Network Control System for a Micro-Flexible Robotic Arm
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批准号:05555071
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$1.34万
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财政年份:1993
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负责人:SASAKI Minoru
-
依托单位:
海外基金