The identification of cell surface antigen of oral streptococcus for development of vaccine for oral cancer

咽峡炎链球菌存在于牙菌斑中，其在口腔粘膜中的感染可能与某些鳞状细胞癌密切相关。本研究以血吸虫纤连蛋白结合蛋白基因为疫苗的研究对象。Fbp62基因在S.调查心绞痛感染情况。结果表明，fbp62基因敲除突变株（Dfbp62）的粘附能力明显降低。与野生型S.心绞痛感染的小鼠。因此，一个新的纤连蛋白结合蛋白的S。Fbp62可能是一种有效的抗心绞痛的候选疫苗。与心绞痛有关的口腔癌

Streptococcus anginosus inhabits dental plaques, and its infection in oral mucosa could be closely related with some squamous cell carcinoma. In this study for the development of vaccine, the fibronectin binding protein gene of S. anginosus, designated fbp62 was cloned, and the pathogenic involvement of Fbp62 in S. anginosusinfection was investigated. The results indicated that the adhesive ability of an fbp62knockout mutan t (Dfbp62) of S. anginosus to mucosal epithelial cells diminished significantly, and that the Dfbp62-infected mice showed considerably lower mortality and abscess formation rates, compared to the wild type S. anginosus-infected mice. Thus, a novel fibronectin binding protein of S. anginosus, Fbp62, could be an effective vaccine candidate for the S. anginosus-related oral cancer.