Mechanisms of abnormal organogenesis and histogenesis of the kidney and ureter and development of the embryonic treatment

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We have clarified that cell rearrangements including convergent extension are involved in elongation of the ureter and ‘elevation’ of the kidney, and observed interkinetic nuclear migration-like nuclear movement in the proliferating epithelial cells of the ureter. The exo-utero manipulation/development system, a method to modify the organogenesis and histogenesis of organs including the ureter, has been improved by echo-guidance and other refinements for the more accurately targeted injection. Although we could not obtain conclusive results in the ureter-related experiments, we could successfully modify the histogenesis in the experiments of the musculoskeletal system.