Exploration of disease-related proteins from spontaneous model of melanoma by proteomics analysis
Exploration of disease-related proteins from spontaneous model of melanoma by proteomics analysis
批准号:
22700457
负责人:
KAWAMOTO Yoshiyuki
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
RET-transgenic (RET-Tg) mice are useful for identifying melanoma-related biomarkers which can predict tumor progression or metastasis. In this study, we found some serum proteins which may relate to melanoma progression or metastasis by proteomic study. In addition, invasive activity of Mel-ret cells, which were established from RET-tg mice, treated with TNF-alpha were enhanced, and some up- or down-regulated genes were identified by DNA array analysis. 2-Dimensional Fluorescence Difference Gel Electrophoresis (2D-DIGE) analysis revealed differential expression of some proteins between B16 melanoma cell line and the highly metastatic cell line B16-F10. In conclusion, we identified some potential candidate for melanoma-related biomarkers.
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DOI:
10.1155/2012/354191
发表时间:
2012
期刊:
Dermatology research and practice
影响因子:
1.5
作者:
[Yajima I, Kumasaka MY, Thang ND, Goto Y, Takeda K, Yamanoshita O, Iida M, Ohgami N, Tamura H, Kawamoto Y, Kato M]
通讯作者:
Kato M
DOI:
10.1091/mbc.e10-08-0724
发表时间:
2011-03-15
期刊:
Molecular biology of the cell
影响因子:
3.3
作者:
[Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M]
通讯作者:
Takahashi M
メラノーマ自然発症RETトランスジェニックマウスを用いた腫瘍関連バイオマーカーの探索
使用患有自发性黑色素瘤的 RET 转基因小鼠寻找肿瘤相关生物标志物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[東岸任弘, 中村昇太, 朴辰幸, 片貝祐子, 保富康宏, 立花太郎, 堀井俊宏, 川本善之]
通讯作者:
川本善之
DOI:
10.4061/2011/896567
发表时间:
2011
期刊:
Enzyme research
影响因子:
--
作者:
[Nakashima I, Kawamoto Y, Takeda K, Kato M]
通讯作者:
Kato M
DOI:
10.1002/jcb.22550
发表时间:
2010-05-15
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
影响因子:
4
作者:
[Kato, Masashi, Takeda, Kozue, Kawamoto, Yoshiyuki]
通讯作者:
Kawamoto, Yoshiyuki
共 7 条
Analysis of anti-tumor activity of interleukin-9 in melanoma models.
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批准号:25430096
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2013
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负责人:KAWAMOTO Yoshiyuki
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依托单位:
Utilization of spontaneous melanoma mice for finding biomarkers
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批准号:19700371
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.37万
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财政年份:2007
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负责人:KAWAMOTO Yoshiyuki
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依托单位:
海外基金