Diet, genes, and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

日本人、巴西日裔人和非日裔巴西人的病例对照研究中的饮食、基因和乳腺癌风险

• 批准号: 22700934
• 负责人: IWASAKI Motoki
• 金额: $ 2.58万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700934/
• 关键词: 遺伝子環境交互作用; 日系移民; 乳がん; 環境要因; 遺伝要因; 交互作用; 症例対照研究

We examined the association between green tea, calcium, vitamin D intake and the risk of breast cancer in case-control studies in Nagano and Sao Paulo. We further investigated gene-environment interaction using genetic polymorphisms related to these dietary factors. No significant association was found between green tea consumption and breast cancer risk and no significant interaction was observed by potential genetic effect modifiers. An inverse association was suggested between calcium and vitamin D intake, and breast cancer risk. We have investigated gene-environment interaction using genetic polymorphisms related to vitamin D receptor gene and blood level of vitamin D.

我们在长野和圣保罗进行的病例对照研究中检测了绿色茶、钙、维生素D摄入量与乳腺癌风险之间的关系。我们进一步研究了基因与环境的相互作用，使用与这些饮食因素相关的遗传多态性。没有发现绿色茶消费和乳腺癌风险之间的显着关联，也没有观察到潜在的遗传效应修饰剂的显着相互作用。钙和维生素D摄入量与乳腺癌风险呈负相关。我们利用维生素D受体基因的遗传多态性和血液中维生素D水平来研究基因-环境相互作用。

项目成果

Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.

东亚人的全基因组关联研究确定了乳腺癌的新易感位点

• DOI: 10.1371/journal.pgen.1002532
• 发表时间: 2012
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Long J;Cai Q;Sung H;Shi J;Zhang B;Choi JY;Wen W;Delahanty RJ;Lu W;Gao YT;Shen H;Park SK;Chen K;Shen CY;Ren Z;Haiman CA;Matsuo K;Kim MK;Khoo US;Iwasaki M;Zheng Y;Xiang YB;Gu K;Rothman N;Wang W;Hu Z;Liu Y;Yoo KY;Noh DY;Han BG;Lee MH;Zheng H;Zhang L;Wu PE;Shieh YL;Chan SY;Wang S;Xie X;Kim SW;Henderson BE;Le Marchand L;Ito H;Kasuga Y;Ahn SH;Kang HS;Chan KY;Iwata H;Tsugane S;Li C;Shu XO;Kang DH;Zheng W
• 通讯作者: Zheng W

緑茶摂取と乳がん罹患との関連:多目的コホート研究より

绿茶摄入量与乳腺癌发病率之间的关联：来自一项多用途队列研究

• 发表时间: 2011
• 作者: 岩崎基;他
• 通讯作者: 他

Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

日本人、巴西日裔人和非日裔巴西人的病例对照研究中膳食异黄酮摄入量、CYP17、CYP19、17β-HSD1 和 SHBG 基因的多态性以及乳腺癌风险

• 发表时间: 2010
• 期刊: Nutr Cancer
• 影响因子: 2.9
• 作者: Iwasaki;M.;et al
• 通讯作者: et al