Longitudinal study for the effect of genetic polymorphism of BRAP, TLR4, APOB gene on the incidence risk of lifestyle related diseases

BRAP、TLR4、APOB基因多态性对生活方式相关疾病发病风险影响的纵向研究

• 批准号: 23300252
• 负责人: SUWAZONO Yasushi
• 金额: $ 12.31万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300252/
• 关键词: 遺伝子多型; メタボリック症候群; 高脂血症; 糖尿病; 追跡調査

The aim of this study was to evaluate the effect of genetic polymorphism for BRCA1 associated protein (BRAP), toll-like receptor 4 (TLR4), apolipoprotein B(APOB) gene on the incidence risk of lifestyle related diseases in a large-scale longitudinal cohort study. Based on the incidences of hypertension, diabetes mellitus, obesity, dyslipidemia, hyperuricemia and high serum gamma-GTP level and the serial change in those related physiological and laboratory results, BRAP gene polymorphism (rs11066001) was shown to have significant effect on the onset of diabetes mellitus and HbA1c level.

本研究旨在通过大规模纵向队列研究，评估BRCA1相关蛋白（BRAP）、toll样受体4 （TLR4）、载脂蛋白B（APOB）基因遗传多态性对生活方式相关疾病发病风险的影响。根据高血压、糖尿病、肥胖、血脂异常、高尿酸血症、血清γ - gtp高发生率及相关生理和实验室结果的系列变化，BRAP基因多态性（rs11066001）对糖尿病的发病和HbA1c水平有显著影响。