Biological Localization and Functionality of Allenic Carotenoids

六烯类胡萝卜素的生物学定位和功能

• 批准号: 23380068
• 负责人: MIYASHITA Kazuo
• 金额: $ 11.98万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380068/
• 关键词: アレンカロテノイド; 抗肥満; 抗糖尿病; フコキサンチン; エネルギー代謝; 抗肥満作用; 抗糖尿病作用; 構造相関; アセチレンカロテノイド; キサントフィル

In the present study, molecular mechanisms were made clear for the anti-obesity effect of fucoxanthin by the induction of UCP1 in abdominal WAT. The anti-obesity effect of fucoxanthin was suggested to be due to its specific structure that contains two carotenoid end rings of the polyene chromophore containing allenic bond and OH and epoxy groups. Therefore, other allenic carotenoids or scission products from fucoxanthin could not show such activities as found in fucoxanthin. Fucoxanthin also improves insulin resistance and decreases blood glucose level through the regulation of adipocytokine secretions from the abdominal WAT. Another important molecular mechanism for the improvement of glucose utilization by fucoxanthin will be glucose transporter 4 (GLUT4) up-regulation and promotion of its translocation to cell membrane from cytosol.

在本研究中，通过诱导腹部WAT中的UCP1，明确了岩藻黄素抗肥胖作用的分子机制。岩藻黄质的减肥作用可能与其特殊的结构有关，即含有两个多烯发色团的类胡萝卜素端环，端环上含有丙二烯键和羟基及环氧基团。因此，其他的联烯类胡萝卜素或岩藻黄质的断裂产物不能显示出岩藻黄质中发现的这种活性。岩藻黄素还通过调节腹部WAT的脂肪细胞因子分泌来改善胰岛素抵抗并降低血糖水平。岩藻黄质提高葡萄糖利用率的另一个重要分子机制是葡萄糖转运蛋白4（GLUT 4）上调并促进其从胞质溶胶转运至细胞膜。

项目成果

Effect of Brown Seaweed Lipids on Fatty Acid Composition and Lipid Hydroperoxide Levels of Mouse Liver

• DOI: 10.1021/jf104643b
• 发表时间: 2011-04-27
• 期刊: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
• 影响因子: 6.1
• 作者: Airanthi, M. K. Widjaja-Adhi;Sasaki, Naoya;Miyashita, Kazuo
• 通讯作者: Miyashita, Kazuo

Combined antiproliferative effect of dietary PPARγ suppressing lipids fucoxanthinol and 1α,25-dihydroxyvitamin D3 in human colon cancer.

膳食 PPARγ 抑制脂质岩藻黄醇和 1α,25-二羟基维生素 D3 在人类结肠癌中的联合抗增殖作用。

• 发表时间: 2013
• 期刊: Carotenoid Sci.
• 作者: Terasaki;M.;Nagao;A.;Maeda;H.;Miyashita;K.;Masuda;S.
• 通讯作者: S.

フコキサンチノール誘導体による脂肪細胞の分化抑制と抗炎症作用に関する研究.

岩藻黄醇衍生物抑制脂肪细胞分化及抗炎作用的研究。

• 发表时间: 2013
• 作者: Nagaoka;S;加賀岳朗・細川雅史・宮下和夫・山野由美子・和田昭盛
• 通讯作者: 加賀岳朗・細川雅史・宮下和夫・山野由美子・和田昭盛

Novel functionality of allenic carotenoids

类胡萝卜素的新功能

• 发表时间: 2011
• 作者: Miyashita;K.
• 通讯作者: K.

Preventive effect of fucoxanthin on oxidative stress in obese-model mice

岩藻黄质对肥胖模型小鼠氧化应激的预防作用

• 发表时间: 2011
• 作者: Airanthi;W.-A.M.K.;Hosokawa;M.;Miyashita;K.
• 通讯作者: K.