Elucidation of the cardiovascular disease by the innovative three-dimensional proteome analytical method

我们分析了创新的三维蛋白质组，考虑到历时分析，这是必要的阐明心血管疾病在这项研究中。我们基于疾病相关因素的疾病蛋白质组分析方法进行生物活性检查，并检查患者的疾病状况。我们的初步临床经验表明，它与再狭窄的存在密切相关。在再狭窄患者中观察到氨基末端加工肽BNP（5-32）相对于BNP（3-32）（作为指标参数BNP[5-32]/BNP[3-32]比值）水平降低。此外，我们还对该致病因子的产生机制进行了研究，并获得了某些蛋白酶参与的知识。我们将考虑这种蛋白酶在血液中具有什么样的活性，并将在未来针对心血管疾病患者的状况进行说明。

We analyzed innovative three-dimensional proteome in consideration of the diachronic analysis that was necessary for the elucidation of the cardiovascular disease in this study. We performed the bioactive examination based on methodology of the disease proteome analysis about a disease-related factor and checked participation in disease condition of a patient. Our initial clinical experience shows that it is strongly associated with presence of restenosis. Reduced levels of the amino-terminal processed peptide, BNP(5-32), relative to BNP(3-32) (as the index parameter BNP[5-32]/BNP[3-32] ratio), were seen in patients with restenosis. In addition, we added examination about the generation mechanism of this disease-related factor and got the knowledge that certain protease participated in. We will consider what kind of activity this protease has in blood and will aim at the condition of a patient elucidation of the cardiovascular disease in future.