Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses
Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses
批准号:
23390314
负责人:
YAMADA Kazuhiko
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
With this grant support, we have successfully established a survival orthotopic intestinal transplantation procedure in MHC-inbred CLAWN miniature swine. To our knowledge, this is the first successful long term, life supporting preclinical intestinal transplantation model in Japan. Our results demonstrated (1 ) compartment syndrome following heterotopic intestine transplantation in CLAWN miniature swine, (2) greater than 3 months acceptance of a life-supporting intestinal grafts, and (3) severe and acute inflammatory cytokine storm in the induction period as well as a strategy to inhibit the cytokine storm (manuscript in preparation).
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MHC 確立クラウンミニブタ小腸移植手技の工夫
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DOI:
--
发表时间:
2014
期刊:
影响因子:
--
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[三浦宏平, 佐原寿史, 河合昭浩, 脇 詩織, 清水 章, 山田和彦]
通讯作者:
山田和彦
DOI:
--
发表时间:
2012
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作者:
[A. Miyatake, T. Nishio, 山田和彦]
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山田和彦
High-mobility group box 1(HMGB1)が腎虚血再灌流障害(IRI)進展に及ぼす役割の大動物モデルによる解明
使用大型动物模型阐明高迁移率族蛋白 1 (HMGB1) 在肾缺血再灌注损伤 (IRI) 进展中的作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[三浦宏平, 佐原寿史, 関島光裕, 河合昭浩, 脇詩織, 清水章, 山田和彦]
通讯作者:
山田和彦
シンポジウム4「臓器保存から臓器蘇生へ-温度を考える」Strategies to reduce ischemia-reperfusion injury (IRI) for expansion of usage of marginal donor organs in a preclinical large animal model of CLAWN miniature swine
研讨会4“从器官保存到器官复苏——考虑温度”减少缺血再灌注损伤(IRI)的策略,扩大CLAWN小型猪临床前大型动物模型中边缘供体器官的使用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
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[Okamura N, Kasuya M, Ishikawa H, Tanaka N, Funaki Y , Iwata R, Meguro K, Y anai K, 山田和彦]
通讯作者:
山田和彦
鹿児島大学医用ミニブタ・先端医療開発研究センターホームページ
鹿儿岛大学医用小型猪/先进医疗开发研究中心主页
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发表时间:
期刊:
影响因子:
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作者:
[]
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