Nucleotide-induced glutamatergic subtype selection of newborn neurons

谷氨酸能神经元是在海马体中产生的。 然而，新生神经元亚型选择的机制尚未阐明。 在这里，我们表明，细胞外核苷酸诱导新生神经元中的谷氨酸能亚型标记物。 药理学研究表明该受体与核苷酸诱导的谷氨酸能分化有关。 在小鼠ES细胞体外神经元分化过程中，相应受体的表达瞬时增强。 这种增强与核苷酸能诱导出谷氨酸能亚型标记的时期相一致。 这些结果表明，细胞外核苷酸可以有助于新生神经元的神经递质亚型的选择。

Glutamategic neurons are produced through life in the hippocampus. However, mechanism determining subtype selection of newborn neurons has not been elucidated. Here, we showed that extracellular nucleotides induced glutamatergic subtype markers in the newborn neurons. Pharmacological study indicated the receptor corresponding to the nucleotide-induced glutamagergic differentiation. Expression of the corresponding receptor was transiently augmented in the course of neuronal differentiation of mouse ES cells in vitro. The augmentation was coincident with the period when nucleotide can induce glutamatergic subtype markers. These results indicate that extracellular nucleotides can contribute to the glutamatergic subtype selection of newborn neurons.