Vergleich der molekularen und zellulären Mechansimen, die die planare Zellpolarität in Drosophila und Vertebraten bestimmen

确定果蝇和脊椎动物平面细胞极性的分子和细胞机制的比较

• 批准号: 5405483
• 负责人: Dr. Mathias Köppen
• 金额: --
• 依托单位: Max-Planck-Institut für molekulare Zellbiologie und Genetik (MPI-CBG)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2003-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5405483?language=en
• 关键词: Vergleich; der; molekularen; und; zellul

The aim of this project is to identify common mechanisms underlying planar cell polarity in Drosophila and in zebrafish. Planar polarization of the Drosophila wing epithelium is reflected by a hair extending from the distal end of each cell. Similarly, gastrulating cells of vertebrates form polarized extensions in the direction of cell movement. In both cases it was shown that planar polarity is controlled by Wnt/Fz-mediated PCP signalling. In the Drosophila wing, PCP signalling controls both the number and polarization of wing hairs. While most studies have focused on the role of PCP signalling in the initial wing hair polarization, much less is known about the function of this signalling pathway in the subsequent control of wing hair number. To better understand this late step of planar polarization, I have chosen to focus on genes such as inturned and fuzzy, as well as newly identified genes, which regulate wing hair number in Drosophila. These genes will be characterized both in the Drosophila wing and during zebrafish gastrulation This will provide new insights into the conserved mechanisms of planar polarization in different biological contexts, and improve our understanding of how molecular mechanisms are used in different organisms to regulate fundamental cellular properties.

这个项目的目的是确定共同的机制，平面细胞极性在果蝇和斑马鱼。果蝇翅上皮细胞的平面极化由从每个细胞的远端延伸的毛发反映。类似地，脊椎动物的原肠胚细胞在细胞运动的方向上形成极化延伸。在这两种情况下，它表明，平面极性控制Wnt/Fz介导的PCP信号。在果蝇翅膀中，PCP信号控制翼毛的数量和极化。虽然大多数研究都集中在PCP信号的作用，在最初的翅毛极化，少得多是已知的功能，这一信号通路在随后的控制翅毛数量。为了更好地理解平面极化的后期步骤，我选择专注于基因，如inturned和fuzzy，以及新发现的基因，这些基因调节果蝇的翅毛数量。这些基因将在果蝇翅膀和斑马鱼原肠胚形成过程中进行表征。这将为不同生物背景下平面极化的保守机制提供新的见解，并提高我们对不同生物体中分子机制如何用于调节基本细胞特性的理解。