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Biosynthesis mechanism of a cyclic antibacterial peptide linked at N- and C- terminal amino acids and elucidation of the cyclization significance

Biosynthesis mechanism of a cyclic antibacterial peptide linked at N- and C- terminal amino acids and elucidation of the cyclization significance
N端和C端氨基酸连接的环状抗菌肽的生物合成机制及其环化意义的阐明
批准号:
23580101
负责人:
KAWAI Yasushi
金额:
$3.49万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
翻译
Gassericin A是由58个氨基酸残基组成的N-和C-末端连接的环状抗菌肽(细菌素),其生物合成基因被鉴定,并且基因表达分析阐明前导序列对Gassericin A的产生是重要的,而不是环化。此外,有人建议gassericin A连接在N-和C-末端氨基酸的ABC-转运蛋白,然后分泌到生产细胞外的前导肽切割后,推定的新型蛋白酶。
英文摘要
A biosynthesis genes for gassericin A, which was the cyclic antibacterial peptide (bacteriocin) linked at N- and C-termini consisting of 58 amino acid residue, were identified, and gene expression analysis clarified that the leader sequence was important to production of gassericin A not the cyclization. In addition, it was suggested gassericin A was linked at N- and C-terminal amino acids by an ABC-transporter and then secreted to outside the producer cells after cleavage of the leader peptide by a putative novel proteinase.
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会议论文
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DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [春日元気, 松島裕樹, 吉田光希, 荒川健佑, 川井泰, 宮本拓, 増田哲也]
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Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research
乳酸菌和双歧杆菌:先进研究的最新进展
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [齋藤忠夫, 伊藤裕之, 岩附慧二, 吉岡俊満編, 井沢真吾, Yasushi Kawai and Tadao Saito, 井沢真吾分担執筆, Yasushi Kawai and Tadao Saito]
通讯作者: Yasushi Kawai and Tadao Saito
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [A. Iwaki, S. Ohnuki, Y. Suga, S. Izawa, and Y. Ohya, 川井泰]
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DOI: --
发表时间: 2014
期刊:
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作者: [齋藤忠夫, 伊藤裕之, 岩附慧二, 吉岡俊満編]
通讯作者: 吉岡俊満編
15
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