Modulation by cytokines of integrin-dependent cancer cell adhesion/invasion to peritoneum
Modulation by cytokines of integrin-dependent cancer cell adhesion/invasion to peritoneum
批准号:
23590092
负责人:
TSUJI Tsutomu
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
The adhesion of cancer cells to peritoneum is an important step in the initial process of peritoneal metastasis of cancer. In this study, we investigated adhesion and invasion of cancer cells by using monolayer culture of peritoneal mesothelial cells. Treatments of cancer cells and mesothelial cells with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 (IL-1) promoted integrin-dependent cell adhesion and invasion in association with increased secretion of matrix-degrading proteinases, indicating that these inflammatory cytokines play crucial roles in peritoneal metastasis of cancer.
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転写因子Ets-1による細胞接着分子α3インテグリンの発現調節
转录因子Ets-1对细胞粘附分子α3整合素表达的调控
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kummasook, A., Cooper, C. R. Jr., Sakamoto, A., Terui, Y., Kashiwagi, K., and Vanittanakorn, N., 新田有香,大河原晋,魚住茉莉,小山裕也,伊藤 潔, 鴨志田剛,辻勉]
通讯作者:
鴨志田剛,辻勉
RGD依存的細胞接着を介した単球の腫瘍馴化マクロファージへの分化とがん細胞接着への影響
单核细胞通过RGD依赖性细胞粘附分化为肿瘤适应巨噬细胞及其对癌细胞粘附的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Malik Suliman, 伊藤潔, 他4名, Hirotaka Imai, 鴨志田剛,辻勉]
通讯作者:
鴨志田剛,辻勉
単球との相互作用によるがん細胞の形質変化-がん細胞浸潤とフィブロネクチンおよびTNF-αの役割-
与单核细胞相互作用导致癌细胞转化 - 癌细胞侵袭以及纤连蛋白和 TNF-α 的作用 -
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[鴨志田剛, 三浦莉紗, 高嶋友理, 鈴木沙由里, 松田彩花, 辻 勉]
通讯作者:
辻 勉
細胞外マトリックスタンパク質を介した単球とがん細胞の相互作用における形質変化
细胞外基质蛋白介导的单核细胞与癌细胞之间相互作用的转变
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sakamoto, A., Terui, Y., Yamamoto, T., Kasahara, T., Nakamura, M., Tomitori, H., Yamamoto, K., Michael, A. J., Igarashi, K., and Kashiwagi, K, 鴨志田剛,松田彩花,桂有沙,三浦莉紗,髙嶋友里,辻勉]
通讯作者:
鴨志田剛,松田彩花,桂有沙,三浦莉紗,髙嶋友里,辻勉
ヒト末梢血単球とがん細胞の相互作用~細胞外マトリックスタンパク質の働きと癌浸潤~
人外周血单核细胞与癌细胞的相互作用-细胞外基质蛋白的功能与癌症侵袭-
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tomitori, H., Suganami, A., Saiki, R., Mizuno, S., Yoshizawa, Y., Masuko, T., Tamura, Y., Nishimura, K., Toida, T., Williams, K., Kashiwagi, K., and Igarashi, K, 鴨志田剛,松田彩花,桂有沙,三浦莉紗,髙嶋友里,辻勉]
通讯作者:
鴨志田剛,松田彩花,桂有沙,三浦莉紗,髙嶋友里,辻勉
共 15 条
The integrin-matrix interaction in the metastasis and invasion processes of cancer
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批准号:19590084
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
-
负责人:TSUJI Tsutomu
-
依托单位:
Regulation of platelet-leukocyte interaction and pharmaceutical application
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批准号:13557213
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.97万
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财政年份:2001
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负责人:TSUJI Tsutomu
-
依托单位:
Characterization of VLA-3 integrin-mediated adhesion and its expre ision in cancer cells
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批准号:13672308
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2001
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负责人:TSUJI Tsutomu
-
依托单位:
Role of VLA-3 integrin in adhesion of cancer cells to peritoneum.
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批准号:11672192
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:TSUJI Tsutomu
-
依托单位:
Relation between activity control of neutrophils and ingestion in inflammation
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批准号:11670426
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.32万
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财政年份:1999
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负责人:TSUJI Tsutomu
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依托单位:
Structure and function of a variation of sialyl Lewis X carbohydrate chains on glycoproteins.
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批准号:09672218
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:TSUJI Tsutomu
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依托单位:
Expression of brain/embryo-type myosin heavy chain isoform in the healing process of damaged tissue
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批准号:09670448
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:TSUJI Tsutomu
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依托单位:
Cell-Biological Study on Medicolegal Diagnosis of Injury
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批准号:07457118
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.62万
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财政年份:1995
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负责人:TSUJI Tsutomu
-
依托单位:
Development of anti-inflammatory drugs affecting functions of platelet adhesion molecules
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批准号:06557134
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$5.06万
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财政年份:1994
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负责人:TSUJI Tsutomu
-
依托单位:
Distribution in Tissue and Biosynthesis of ABO Blood Group Substances Specific for Tissue.
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批准号:03454214
-
项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$1.98万
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财政年份:1991
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负责人:TSUJI Tsutomu
-
依托单位:
Molecular Analysis of Platelet-Immunocyte Interaction
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批准号:03671045
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:TSUJI Tsutomu
-
依托单位:
海外基金