Investigation for complement D factor activation by MASP-1/3
Investigation for complement D factor activation by MASP-1/3
批准号:
23590342
负责人:
TAKAHASHI Minoru
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
点击翻译按钮获取中文摘要
英文摘要
In complement system, lectin pathway activates complement by recognition of sugar chains on microbes. MASP has a pivotal role in the lectin pathway. Three MASPs (MASP-1, MASP-2 and MASP-3) were identified. We reported that MASP-1/3 activate complement D factor(fD), which is essential for the alternative pathway. In this study, we will investigate the mechanisms for activation of fD by MASP-1/3. During this study, MASP-1/3 defected patients were found. We found that MASP1/3 is essential for alternative pathway in human as well as mouse.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial, gastrointestinal ischemia/reperfusion injury
甘露聚糖结合凝集素相关丝氨酸蛋白酶-2 的靶向可提供针对心肌、胃肠道缺血/再灌注损伤的保护
DOI:
--
发表时间:
2011
期刊:
Proc Natl Acad Sci U S A
影响因子:
--
作者:
[Schwaeble W. J., Lynch N. J., Clark J. E., Marber M., Samani N. J., Ali Y. M., Dudler T., Parent B., Lhotta K., Wallis R., Farrar C. A., Sacks S., Lee H., Zhang M., Iwaki D., Takahashi M., Fujita T., Tedford C. E., Stover C. M.]
通讯作者:
Stover C. M.
Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”
对“甘露聚糖结合凝集素相关丝氨酸蛋白酶 (MASP)-1 对于人血清中凝集素途径激活至关重要,而替代途径功能不需要 MASP-1 和 MASP-3”的评论
DOI:
10.4049/jimmunol.1390002
发表时间:
2013
期刊:
The Journal of Immunology
影响因子:
--
作者:
[Minoru Takahashi, H. Sekine, Y. Endo, T. Fujita]
通讯作者:
T. Fujita
Mannose-binding lectin, its associated proteases (MASPs) mediate coagulation, its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
甘露糖结合凝集素及其相关蛋白酶 (MASP) 介导凝血,其缺乏是发生感染并发症(包括弥散性血管内凝血)的危险因素
DOI:
--
发表时间:
2011
期刊:
Immunobiology
影响因子:
2.8
作者:
[Takahashi K., Chang W. C., Takahashi M., Pavlov V., Ishida Y., La Bonte L., Shi L., Fujita T., Stahl G. L., Van Cott E. M.]
通讯作者:
Van Cott E. M.
高橋実、関根英治、遠藤雄一、藤田禎三
高桥稔、关根英二、远藤雄一、藤田贞三
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[神尾明君, 武谷 立, 田ノ上禎久, 富永隆治, 住本英樹, 河邉真也, MASP1/3欠損マウスにおける形態異常・3MC症候群との関連]
通讯作者:
MASP1/3欠損マウスにおける形態異常・3MC症候群との関連
DOI:
10.4049/jimmunol.1102916
发表时间:
2012-01-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[La Bonte LR, Pavlov VI, Tan YS, Takahashi K, Takahashi M, Banda NK, Zou C, Fujita T, Stahl GL]
通讯作者:
Stahl GL
共 22 条
Effects of feedback information about visual attention under the exposure trial
-
批准号:17K04443
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2017
-
负责人:TAKAHASHI Minoru
-
依托单位:
Exploring the changing visual attention under the exposure therapy using eye-tracking device
-
批准号:26380946
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:TAKAHASHI Minoru
-
依托单位:
Effect of word for decreasing unpleasantness under the exposure to fear stimuli
-
批准号:23730665
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2011
-
负责人:TAKAHASHI Minoru
-
依托单位:
Comprehensive research on the archives of the Shogunate and lords in the Edo period
-
批准号:22320136
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.48万
-
财政年份:2010
-
负责人:TAKAHASHI Minoru
-
依托单位:
Effects of Acceptance strategy that was based on Applied Behavior Analysis
-
批准号:19730437
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.26万
-
财政年份:2007
-
负责人:TAKAHASHI Minoru
-
依托单位:
Correlation functions of solvable models and thermal transport phenomena
-
批准号:18340112
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.85万
-
财政年份:2006
-
负责人:TAKAHASHI Minoru
-
依托单位:
Pore Control of Porous Insulation Ceramics for Building Materials Fabricated by in-situ Solidification Method
-
批准号:15310052
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.96万
-
财政年份:2003
-
负责人:TAKAHASHI Minoru
-
依托单位:
Theoretical and Numerical Study of Many-Body Interaction and Quantum Phase Transition in Low-Dimensional Magnets
-
批准号:14340099
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.38万
-
财政年份:2002
-
负责人:TAKAHASHI Minoru
-
依托单位:
Development of gene therapy for advanced gastrointestinal cancer utilizing novel mutant p53 gene with effective nuclear translocation
-
批准号:13670535
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2001
-
负责人:TAKAHASHI Minoru
-
依托单位:
Theoretical and Numerical Study of Many-Body Interaction and Quantum Phase Transition in Low-Dimensional Magnets
-
批准号:11440103
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:1999
-
负责人:TAKAHASHI Minoru
-
依托单位:
Antiangiogenesis gene therapy for advanced hepatocellular carcinoma by transferrin-DNA conjugate.
-
批准号:11670520
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:1999
-
负责人:TAKAHASHI Minoru
-
依托单位:
Study of Critical Phenomena in Low-Dimensional Magnets
-
批准号:08640445
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.96万
-
财政年份:1996
-
负责人:TAKAHASHI Minoru
-
依托单位:
Study of Japan-China Cultural Exchanges up to The Mid-19C.
-
批准号:06045003
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$3.65万
-
财政年份:1994
-
负责人:TAKAHASHI Minoru
-
依托单位:
Fundamental Study on Boiling of Liquid-metal for Cooling of Magnetically Confined Fusion Reactor
-
批准号:02808039
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1990
-
负责人:TAKAHASHI Minoru
-
依托单位:
国内基金
海外基金
登录
查看更多内容
基于MALDI-TOF MS结合电子倍增技术的血清外泌体完整蛋白UPAR和MASP2定量方法研究及其临床应用
-
批准号:82302641
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2023
-
负责人:闪亮
-
依托单位:
重组蜘蛛主腺体丝蛋白MaSp1在仿生微流体器件中的自组装机理研究
-
批准号:52303281
-
项目类别:青年科学基金项目
-
资助金额:30.00万元
-
批准年份:2023
-
负责人:陈剑铭
-
依托单位:
新冠病毒N蛋白与MASP2相互作用及其在补体凝集素途径过度活化介导炎症失控和急性肺损伤中的机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2021
-
负责人:刘毅
-
依托单位:
内源性脂肪分泌肽MASP3抑制乳腺癌侵袭转移的应用基础研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:54.7万元
-
批准年份:2021
-
负责人:付子毅
-
依托单位:
VEGF通过磷酸化MASP1调节补体系统活化在HELLP综合征发病中的机制研究
-
批准号:82071668
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2020
-
负责人:赫英东
-
依托单位:
MASP-2效应酶介导感染性肉芽肿形成、成熟的免疫调节机制研究
-
批准号:31370912
-
项目类别:面上项目
-
资助金额:15.0万元
-
批准年份:2013
-
负责人:马兴铭
-
依托单位: