Investigation for complement D factor activation by MASP-1/3

MASP-1/3 对补体 D 因子激活的研究

• 批准号: 23590342
• 负责人: TAKAHASHI Minoru
• 金额: $ 3.08万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590342/
• 关键词: 補体; MASP; ノックアウトマウス; 3MC症候群; レクチン経路; トランスジェニック

In complement system, lectin pathway activates complement by recognition of sugar chains on microbes. MASP has a pivotal role in the lectin pathway. Three MASPs (MASP-1, MASP-2 and MASP-3) were identified. We reported that MASP-1/3 activate complement D factor(fD), which is essential for the alternative pathway. In this study, we will investigate the mechanisms for activation of fD by MASP-1/3. During this study, MASP-1/3 defected patients were found. We found that MASP1/3 is essential for alternative pathway in human as well as mouse.

在补体系统中，凝集素途径通过识别微生物上的糖链来激活补体。 MASP 在凝集素途径中发挥着关键作用。确定了三个 MASP（MASP-1、MASP-2 和 MASP-3）。我们报道了 MASP-1/3 激活补体 D 因子 (fD)，这对于替代途径至关重要。在本研究中，我们将研究 MASP-1/3 激活 fD 的机制。在这项研究中，发现了 MASP-1/3 缺陷的患者。我们发现 MASP1/3 对于人类和小鼠的替代途径至关重要。

项目成果

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial, gastrointestinal ischemia/reperfusion injury

甘露聚糖结合凝集素相关丝氨酸蛋白酶-2 的靶向可提供针对心肌、胃肠道缺血/再灌注损伤的保护

• 发表时间: 2011
• 期刊: Proc Natl Acad Sci U S A
• 作者: Schwaeble W. J.;Lynch N. J.;Clark J. E.;Marber M.;Samani N. J.;Ali Y. M.;Dudler T.;Parent B.;Lhotta K.;Wallis R.;Farrar C. A.;Sacks S.;Lee H.;Zhang M.;Iwaki D.;Takahashi M.;Fujita T.;Tedford C. E.;Stover C. M.
• 通讯作者: Stover C. M.

Comment on “Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function”

对“甘露聚糖结合凝集素相关丝氨酸蛋白酶 (MASP)-1 对于人血清中凝集素途径激活至关重要，而替代途径功能不需要 MASP-1 和 MASP-3”的评论

• DOI: 10.4049/jimmunol.1390002
• 发表时间: 2013
• 期刊: The Journal of Immunology
• 作者: Minoru Takahashi;H. Sekine;Y. Endo;T. Fujita
• 通讯作者: T. Fujita

Mannose-binding lectin, its associated proteases (MASPs) mediate coagulation, its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

甘露糖结合凝集素及其相关蛋白酶 (MASP) 介导凝血，其缺乏是发生感染并发症（包括弥散性血管内凝血）的危险因素

• 发表时间: 2011
• 期刊: Immunobiology
• 影响因子: 2.8
• 作者: Takahashi K.;Chang W. C.;Takahashi M.;Pavlov V.;Ishida Y.;La Bonte L.;Shi L.;Fujita T.;Stahl G. L.;Van Cott E. M.
• 通讯作者: Van Cott E. M.

高橋実、関根英治、遠藤雄一、藤田禎三

高桥稔、关根英二、远藤雄一、藤田贞三

• 发表时间: 2012
• 作者: 神尾明君;武谷 立;田ノ上禎久;富永隆治;住本英樹;河邉真也;MASP1/3欠損マウスにおける形態異常・3MC症候群との関連
• 通讯作者: MASP1/3欠損マウスにおける形態異常・3MC症候群との関連

Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis.

• DOI: 10.4049/jimmunol.1102916
• 发表时间: 2012-01-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: La Bonte LR;Pavlov VI;Tan YS;Takahashi K;Takahashi M;Banda NK;Zou C;Fujita T;Stahl GL
• 通讯作者: Stahl GL