Shared mechanisms of the transcription factor IRF8 and the cAMP pathway in macrophage differentiation

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Cell differentiation requires appropriate changes in gene expression patterns, which are tightly regulated by cell type-specific transcription factors. Dysregulation of these processes can result in disorders incuding leukemias. IRF8 is a hematopoietic transcription factor that regulates the development of multiple immune cell types, and also it is considered as an important regulatory factor for chronic myelogenous leukemia. In this study, we have investigated the differentiation program of myeloid cells by functional analyses of IRF8 with the aim of the future clinical application for chronic myelogenous leukemia. We performed gene expression profiling of macrophage differentiation induced by multiple procedures including IRF8 ectopic expression. We found the common transcription factors in macrophage differentiation induced by multiple procedures. Indeed, the ectopic expression of these transcription factors induced macrophage differentiation without IRF8 expression.