Understandings of the HPV-induced tumorigenesis for developing anti-virus reagents.

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The infection of HPV is a major risk factor for cervical cancers and some of head and neck squamous cell carcinomas. For prevention of these cancers, it is critical to develop effective anti-virus reagents. In this project, I examined the mechanisms of virus replication and virus-induced tumorigenesis for identification of the candidate targets for anti-virus reagents.It was revealed that E6 was important for the genome maintenance of HPV and that E7 was critical both for the virus-induced tumorigenesis and vegetative virus replication.These results indicates that both E6 and E7 are good candidates for the developing anti-virus reagents. For the identification of the reagents, it is essential to clarify the action mechanisms of these oncoproteins.