A novel biomarker predicting the response to pegylated interferon-alpha plus ribavirin in patients with chronic hepatitis C

点击翻译按钮获取中文摘要

Novel biomarkers predicting sustained virological response (SVR) to pegylated interferon alpha plus ribavirin (PEG-IFNalpha/RBV) were investigated. Peptides in pretreatment sera from patients with hepatitis C virus (HCV) were comprehensively analyzed by mass spectrometry. In total, 107 peptides were detected in a training set (n=23). In all the responders (who achieved SVR) and the non-responders (n=96), sensitivity and specificity of SVR in a model consisting of ion intensity of 107 peptides, hemoglobin, BMI, and age were 70% and 92%, and those in another model consisting of ion intensity of complement 3f des-arginine (C3f-dR) and platelet count were 59% and 88%, respectively. Taken together, serum peptides, especially C3f-dR, would be useful predictors for SVR to PEG-IFNalpha/RBV. The complements may be involved in the HCV elimination.