A novel biomarker predicting the response to pegylated interferon-alpha plus ribavirin in patients with chronic hepatitis C

研究了预测聚乙二醇化干扰素α +利巴韦林（peg - ifn α /RBV）持续病毒学反应（SVR）的新型生物标志物。采用质谱法对丙型肝炎病毒（HCV）患者预处理血清中的多肽进行了全面分析。在一个训练集中总共检测到107个多肽（n=23）。在所有应答者（达到SVR）和无应答者（n=96）中，由107肽离子强度、血红蛋白、BMI和年龄组成的模型中SVR的敏感性和特异性分别为70%和92%，由补体3f-去精氨酸（C3f-dR）离子强度和血小板计数组成的模型中SVR的敏感性和特异性分别为59%和88%。综上所述，血清肽，特别是C3f-dR，将是对peg - ifna - α /RBV的SVR的有用预测因子。补体可能参与HCV的消除。

Novel biomarkers predicting sustained virological response (SVR) to pegylated interferon alpha plus ribavirin (PEG-IFNalpha/RBV) were investigated. Peptides in pretreatment sera from patients with hepatitis C virus (HCV) were comprehensively analyzed by mass spectrometry. In total, 107 peptides were detected in a training set (n=23). In all the responders (who achieved SVR) and the non-responders (n=96), sensitivity and specificity of SVR in a model consisting of ion intensity of 107 peptides, hemoglobin, BMI, and age were 70% and 92%, and those in another model consisting of ion intensity of complement 3f des-arginine (C3f-dR) and platelet count were 59% and 88%, respectively. Taken together, serum peptides, especially C3f-dR, would be useful predictors for SVR to PEG-IFNalpha/RBV. The complements may be involved in the HCV elimination.