Effects of compounds isolated from traditional drugs on UV-induced photochemotherapy and carcinogenesis and their mechanisms

从传统药物中分离的化合物对紫外线诱导的光化疗和致癌作用的影响及其机制

• 批准号: 23590883
• 负责人: KIMURA Yoshiyuki
• 金额: $ 3.24万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590883/
• 关键词: 癌; 植物成分; 薬理学; 生理活性; 紫外線

Tetrahydroxy-dimethoxyflavone and Pentahydroxyflavanone isolated from Scutellariae Radix inhibited the acute UVB-induced skin inflammation through the inhibition of MMP-9 expression and VEGF production. We found that wogonin isolated from Scutellariae Radix had anti-tumor and anti-metastatic actions through anti-lymphangiogenesis. We found that the anti-proliferative and anti-tumor actions of UVA plus furocoumarins isolated from Umbelliferae medicinal plants were due to G2/M arrest of the cell cycle by an increase in phospho-Chk1 and decrease in phospho-cdc2 of melanoma cells.

黄芩中的四羟基二甲氧基黄酮酮和五羟基黄酮酮通过抑制MMP9的表达和血管内皮生长因子的产生而抑制UVB诱导的急性皮肤炎症。我们发现从黄芩中分离得到的汉黄藤素具有抗肿瘤和抗转移的作用，其机制可能是通过抑制淋巴管生成。我们发现，从伞形科药用植物中分离的UVA和呋喃香豆素的抗增殖和抗肿瘤作用是由于黑色素瘤细胞的磷酸化Chk1增加和磷酸化cdc2减少而使细胞周期发生G2/M期停滞。

项目成果

Anti-tumor and anti-metastatic actons of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis

从黄芩根中分离出的汉黄芩素通过抗淋巴管生成具有抗肿瘤和抗转移作用

• 发表时间: 2013
• 期刊: Phytomedicine
• 影响因子: 7.9
• 作者: Yoshiyuki Kimura;M. Sumiyoshi
• 通讯作者: M. Sumiyoshi

Photochemotherapy by ultraviolet A plus furocoumarins isolated from Angelica species in B16F10-bearing hairless mice

使用紫外线 A 加上从当归属中分离的呋喃香豆素对 B16F10 荷载无毛小鼠进行光化疗

• 发表时间: 2012
• 作者: Kimura Y;Sumiyoshi M;Taniguchi M;Baba K
• 通讯作者: Baba K

Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice

• DOI: 10.1016/j.ejphar.2011.04.033
• 发表时间: 2011-07-01
• 期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
• 影响因子: 5
• 作者: Kimura, Yoshiyuki;Sumiyoshi, Maho
• 通讯作者: Sumiyoshi, Maho

紫外線A波(UVA)照射下におけるセリ科植物由来のクマリン類の抗腫瘍効果とその作用機構

伞形科植物香豆素在紫外线A（UVA）照射下的抗肿瘤作用及作用机制

• 发表时间: 2013
• 作者: 木村善行;住吉真帆;阪中雅広;谷口雅彦;馬場きみ江
• 通讯作者: 馬場きみ江

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation

• DOI: 10.1007/s11418-013-0774-z
• 发表时间: 2014-01-01
• 期刊: JOURNAL OF NATURAL MEDICINES
• 影响因子: 3.3
• 作者: Sumiyoshi, Maho;Sakanaka, Masahiro;Kimura, Yoshiyuki
• 通讯作者: Kimura, Yoshiyuki