Effects of compounds isolated from traditional drugs on UV-induced photochemotherapy and carcinogenesis and their mechanisms

从传统药物中分离的化合物对紫外线诱导的光化疗和致癌作用的影响及其机制

• 批准号: 23590883
• 负责人: KIMURA Yoshiyuki
• 金额: $ 3.24万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590883/
• 关键词: 癌; 植物成分; 薬理学; 生理活性; 紫外線

Tetrahydroxy-dimethoxyflavone and Pentahydroxyflavanone isolated from Scutellariae Radix inhibited the acute UVB-induced skin inflammation through the inhibition of MMP-9 expression and VEGF production. We found that wogonin isolated from Scutellariae Radix had anti-tumor and anti-metastatic actions through anti-lymphangiogenesis. We found that the anti-proliferative and anti-tumor actions of UVA plus furocoumarins isolated from Umbelliferae medicinal plants were due to G2/M arrest of the cell cycle by an increase in phospho-Chk1 and decrease in phospho-cdc2 of melanoma cells.

黄芪中的四羟基二甲氧基黄酮和五羟基黄烷酮通过抑制MMP-9的表达， VEGF产生。结果表明，汉黄芩素具有抗肿瘤和抗转移作用，其作用机制可能与抑制淋巴管生成有关。 我们发现UVA和从伞形科药用植物中分离的呋喃香豆素的抗增殖和抗肿瘤作用是由于细胞的G2/M阻滞 通过增加黑色素瘤细胞的磷酸-Chk 1和减少磷酸-cdc 2来调节细胞周期。

项目成果

Anti-tumor and anti-metastatic actons of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis

从黄芩根中分离出的汉黄芩素通过抗淋巴管生成具有抗肿瘤和抗转移作用

• 发表时间: 2013
• 期刊: Phytomedicine
• 影响因子: 7.9
• 作者: Yoshiyuki Kimura;M. Sumiyoshi
• 通讯作者: M. Sumiyoshi

Photochemotherapy by ultraviolet A plus furocoumarins isolated from Angelica species in B16F10-bearing hairless mice

使用紫外线 A 加上从当归属中分离的呋喃香豆素对 B16F10 荷载无毛小鼠进行光化疗

• 发表时间: 2012
• 作者: Kimura Y;Sumiyoshi M;Taniguchi M;Baba K
• 通讯作者: Baba K

Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice

• DOI: 10.1016/j.ejphar.2011.04.033
• 发表时间: 2011-07-01
• 期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
• 影响因子: 5
• 作者: Kimura, Yoshiyuki;Sumiyoshi, Maho
• 通讯作者: Sumiyoshi, Maho

紫外線A波(UVA)照射下におけるセリ科植物由来のクマリン類の抗腫瘍効果とその作用機構

伞形科植物香豆素在紫外线A（UVA）照射下的抗肿瘤作用及作用机制

• 发表时间: 2013
• 作者: 木村善行;住吉真帆;阪中雅広;谷口雅彦;馬場きみ江
• 通讯作者: 馬場きみ江

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation

• DOI: 10.1007/s11418-013-0774-z
• 发表时间: 2014-01-01
• 期刊: JOURNAL OF NATURAL MEDICINES
• 影响因子: 3.3
• 作者: Sumiyoshi, Maho;Sakanaka, Masahiro;Kimura, Yoshiyuki
• 通讯作者: Kimura, Yoshiyuki